Medtronic, Inc.

1 ARTICLES PUBLISHED IN JoVE

JoVE Core

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine

Tinen L. Iles¹, Brian Howard², Stephen Howard³, Stephen Quallich², Christopher Rolfes², Eric Richardson⁴, Hanna R. Iaizzo⁵, Paul A. Iaizzo¹

¹Surgery, University of Minnesota, ²Biomedical Engineering, University of Minnesota, ³Medtronic, Inc., ⁴Bioengineering, Rice University, ⁵Pharmacy, University of Wisconsin

We have developed a swine model for the target delivery of pharmacological agents within the pericardial space/fluid. Using this approach, the relative benefits of administered agents on induced atrial fibrillation, relative refractory periods and/or ischemic protection can be investigated.