Ascending Aortic Constriction in Rats for Creation of Pressure Overload Cardiac Hypertrophy ModelAjith Kumar GS *1, Binil Raj *1, Santhosh Kumar S 2, Sanjay G 3, Chandrasekharan Cheranellore Kartha 1
1Cardio Vascular Disease Biology, Rajiv Gandhi Centre for Biotechnology, 2Animal Research Facility, Rajiv Gandhi Centre for Biotechnology, 3Cardiology Department, Sree Chitra Tirunal Institute for Medical Sciences & Technology
We describe a stepwise procedure for creating pressure overload and left ventricular hypertrophy in Wistar rats by constriction of the ascending aorta using a small metallic clip. This model is extensively used for studying remodeling changes during cardiac hypertrophy and for identifying and evaluating strategies for regression of such changes.
