Xenograft Skin Model to Manipulate Human Immune Responses In VivoMadison I. Moss 1, Mariela Pauli 2, Joshua M. Moreau 1, Jarish N. Cohen 1, Michael D. Rosenblum 1, Margaret M. Lowe 1
1Department of Dermatology, UCSF, 2TRex Bio
The present protocol describes how to graft human skin onto non-obese diabetic (NOD)-scid interleukin-2 gamma chain receptor (NSG) mice. A detailed description of the preparation of human skin for transplant, preparation of mice for transplant, transplantation of split-thickness human skin, and post-transplantation recovery procedure are included in the report.
