University of Basel Hospital

3 ARTICLES PUBLISHED IN JoVE

Behavior

An Objective and Child-friendly Assessment of Arm Function by Using a 3-D Sensor

Xing Chen¹, Detlef Wolf¹, Juliane Siebourg-Polster², Christian Czech³, Ulrike Bonati^4,5, Dirk Fischer^4,5, Omar Khwaja⁶, Martin Strahm¹

¹Data Science, Roche Pharmaceutical Research and Early Development Informatics, Roche Innovation Center Basel, F. Hoffmann-La Roche, Ltd., ²Translational Technologies and Bioinformatics, Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Ltd., ³Biomarker Experimental Medicine, Neuroscience, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Ltd., ⁴Division of Neuropediatrics, University of Basel Children's Hospital, ⁵Department of Neurology, University of Basel Hospital, ⁶Translational Medicine, Neuroscience and Rare Diseases, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Ltd.

An objective measure of muscle functions is challenging especially in children. Based on a commercially available digital 3-D sensor, a child-friendly gaming test was developed to assess upper limb function for clinical trials.

Medicine

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy

Sara Nagy^1,2, Simone Schmidt^1,2, Patricia Hafner^1,3, Andrea Klein^1,4,5, Daniela Rubino-Nacht¹, Vanya Gocheva¹, Oliver Bieri⁶, Carole Vuillerot⁷, Ulrike Bonati^1,2, Dirk Fischer^1,2,3

¹Division of Pediatric Neurology, University Children's Hospital Basel (UKBB), University of Basel, ²Department of Neurology, University Hospital Basel, University of Basel, ³Division of Neurology, University Clinic of Medicine, Cantonal Hospital Baselland, Bruderholz, ⁴Division of Pediatric Neurology, CHUV, ⁵Division of Neuropaediatrics, Inselspital, University Children's Hospital Bern, ⁶Department of Radiology, Division of Radiological Physics, University Hospital Basel, University of Basel, ⁷Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, L'Escale, Service de Médecine Physique et de Réadaptation Pédiatrique

The aim of this study is to present the most reliable clinical outcome measures and their correlations with quantitative muscle MRI in ambulant patients with Duchenne muscular dystrophy.

Neuroscience

Whole Neonatal Cochlear Explants as an In vitro Model

Soledad Levano¹, Yu Lu¹, Maurizio Cortada¹, Daniel Bodmer^1,2

¹Department of Biomedicine, University of Basel Hospital, ²Department of Otorhinolaryngology, Head and Neck Surgery, University of Basel Hospital

The current protocol updates previous protocols and incorporates relatively straightforward approaches for culturing high-quality cochlear explants. This provides reliable data acquisition and high-resolution imaging in live and fixed cells. This protocol supports the ongoing trend of studying inner ear cells.