A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
Results: C6orf-70-knockdown Alters Radial Migration of Cortical Neurons
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Conclusion
副本
The overall goal of this procedure is to identify novel candidate genes for brain malformation disorders and to directly confirm their causative role in-vivo. This strategy can help answer key questions in the field of neurobiology by discovering
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Periventricular nodular heterotopia (PNH) is the most common form of malformation of cortical development (MCD) in adulthood but its genetic basis remains unknown in most sporadic cases. We have recently developed a strategy to identify novel candidate genes for MCDs and to directly confirm their causative role in vivo.