Precursor Preparation: Synthesis of Methyl 4-(N-hydroxyacetamido) Benzoate
4:33
Synthesis of Methyl 4-(N-trifluoromethoxy)acetamido) Benzoate
5:58
Synthesis of Methyl 4-Acetamido-3-(trifluoromethoxy) Benzoate via Trifluoromethoxy-migration
7:14
Results: Synthesis of Trifluoromethoxylated Aniline Derivatives Using Togni Reagent II
8:12
Conclusion
Transcript
The overall goal of this protocol is to synthesize novel ortho-trifluoromethoxylated anilines with the discovery and development of new drugs, agrochemicals, and functional materials. This method can help to answer key questions in the field of fo
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An operationally simple procedure for the synthesis of ortho-trifluoromethoxylated aniline derivatives via a two-step sequence of O-trifluoromethylation of N-aryl-N-hydroxyacetamide followed by thermally induced intramolecular OCF3-migration is reported.
