The overall goal of this procedure is to measure fatigue-like behavior in mice to establish a fatigue model, and test whether intervention can reverse the fatigue. This method can help answer key questions relating to fatigue, such as what interve
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Fatigue is a common, undertreated and frequently poorly-understood symptom in many diseases and disorders. New preclinical assays of fatigue may help to improve current understanding and future treatment of fatigue. To that end, the current protocol provides a novel means of measuring fatigue-like behavior in the mouse.