Results: Reconstitution of Hematopoietic Cells in Mice Using Transduction-Transplantation
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Conclusion
副本
The overall goal of this procedure is to generate mice expressing the gene of interest in hematopoietic cells using the transduction-transplantation method. Within a short period of time, this method can help answer whether your gene of interest i
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This manuscript provides a description of the methodology used to establish transduction-transplantation mouse models. A detailed account is given of technical errors to avoid when performing bone marrow transplants. A clear understanding should be gained of the importance of high viral titer, transfection/transduction, and irradiation.