Preparation of the Gd(III) Dendrimeric Constrast Agent (DCA)
6:28
In Vitro Characterization of a Dendrimeric Contrast Agent (DCA) and Monomeric Analogue (GdDOTA)
9:09
Results: Dendrimeric Contrast Agent Activity
10:38
Conclusion
副本
The overall goal of this procedure is to show the preparation and characterization of a dendrimeric paramagnetic chelating which can be used as a contrast agent for magnetic resonance imaging and to demonstrate its performance in an imaging experi
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This protocol describes the preparation and characterization of a dendrimeric magnetic resonance imaging (MRI) contrast agent that carries cyclen-based macrocyclic chelates coordinating paramagnetic gadolinium ions. In a series of MRI experiments in vitro, this agent produced an amplified MRI signal when compared to the commercially available monomeric analogue.