Neurodenegration in many neurological disorders is a chronic process of which neuronal fiber loss often occurs prior to the cell body loss. The stereological quantification of neuronal fibers in three dimensions provides a sensitive and accurate m
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Neuronal fiber length within a three-dimensional structure of a brain region is a reliable parameter to quantify specific neuronal structural integrity or degeneration. This article details a stereological quantification method to measure cholinergic fiber length within the nucleus basalis of Meynert in mice as an example.