First Experimental Animals and Mouse OIR Model Induction
1:59
Drug Administration (Optional)
3:22
Tissue Collection and Preparation of Retinal Flat Mounts
6:57
Results: Rat and Mouse Models of OIR
8:39
Conclusion
Transcript
After its development, the oxygen-induced retinopathy model has become widely used in preclinical studies of neovascular retinal diseases. It has been used as a model to study pathological angiogenesis in response to hypoxia. The main advantage of
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Oxygen-induced retinopathy (OIR) can be used to model ischemic retinal diseases such as retinopathy of prematurity and proliferative diabetic retinopathy and to serve as a model for proof-of-concept studies in evaluating antiangiogenic drugs for neovascular diseases. OIR induces robust and reproducible neovascularization in the retina that can be quantified.
