Our open-chest approach, in which we include ventilation with positive end-expiratory pressure, is significant to assess and analyze cardiac function in vivo, and the increase in beta-adrenergic stimulation. The procedure can be used to address bo
Sign in or start your free trial to access this content
Here we describe a cardiac pressure-volume loop analysis under increasing doses of intravenously infused isoproterenol to determine the intrinsic cardiac function and the β-adrenergic reserve in mice. We use a modified open-chest approach for the pressure-volume loop measurements, in which we include ventilation with positive end-expiratory pressure.
