Results: Comparing Transplantation Efficiency of Murine AML Cells Using Retro-Orbital and Intra-Peritoneal Routes of Transplantation
9:29
Conclusion
副本
This protocol is significant because lin-negative cells and SK cells isolated from the same donor mice had no apparent difference in the generation of MLL-AF9 induced AML. Also, IP injection of leukemic cells can successfully develop a mouse model
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Here, intra-peritoneal injection of leukemia cells is utilized to establish and propagate acute myeloid leukemia (AML) in mice. This new method is effective in the serial transplantation of AML cells and can serve as an alternative for those who may experience difficulties and inconsistencies with intravenous injection in mice.
