Bernd Schmeck

Reduction of tumor necrosis factor-alpha (TNF-alpha) related nuclear factor-kappaB (NF-kappaB) translocation but not inhibitor kappa-B (Ikappa-B)-degradation by Rho protein inhibition in human endothelial cells.

Rho protein inactivation induced apoptosis of cultured human endothelial cells.

Adrenomedullin reduces endothelial hyperpermeability.

Rho protein inhibition blocks cyclooxygenase-2 expression by proinflammatory mediators in endothelial cells.

Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae.

Streptococcus pneumoniae-induced caspase 6-dependent apoptosis in lung epithelium.

Porphyromonas gingivalis strain-dependent activation of human endothelial cells.

Streptococcus pneumoniae-induced p38 MAPK-dependent phosphorylation of RelA at the interleukin-8 promotor.

Neuronal plasticity in persistent perennial allergic rhinitis.

Nod1-mediated endothelial cell activation by Chlamydophila pneumoniae.

Adrenomedullin reduces Staphylococcus aureus alpha-toxin-induced rat ileum microcirculatory damage.

Adhesion of Moraxella catarrhalis to human bronchial epithelium characterized by a novel fluorescence-based assay.

Streptococcus pneumoniae R6x induced p38 MAPK and JNK-mediated caspase-dependent apoptosis in human endothelial cells.

Intracellular bacteria differentially regulated endothelial cytokine release by MAPK-dependent histone modification.

Pneumococci induced TLR- and Rac1-dependent NF-kappaB-recruitment to the IL-8 promoter in lung epithelial cells.

Mechanisms of Chlamydophila pneumoniae-mediated GM-CSF release in human bronchial epithelial cells.

Adrenomedullin treatment abolishes ileal mucosal hypoperfusion induced by Staphylococcus aureus alpha-toxin--an intravital microscopic study on an isolated rat ileum.

Listeria monocytogenes activated p38 MAPK and induced IL-8 secretion in a nucleotide-binding oligomerization domain 1-dependent manner in endothelial cells.

Moraxella catarrhalis induces inflammatory response of bronchial epithelial cells via MAPK and NF-kappaB activation and histone deacetylase activity reduction.

Streptococcus pneumoniae induced p38 MAPK- and NF-kappaB-dependent COX-2 expression in human lung epithelium.

Perturbation of endothelial junction proteins by Staphylococcus aureus alpha-toxin: inhibition of endothelial gap formation by adrenomedullin.

Role of pneumolysin for the development of acute lung injury in pneumococcal pneumonia.

Lung epithelium as a sentinel and effector system in pneumonia--molecular mechanisms of pathogen recognition and signal transduction.

Streptococcus pneumoniae induced c-Jun-N-terminal kinase- and AP-1 -dependent IL-8 release by lung epithelial BEAS-2B cells.

Listeria monocytogenes induced Rac1-dependent signal transduction in endothelial cells.

Legionella pneumophila induces IFNbeta in lung epithelial cells via IPS-1 and IRF3, which also control bacterial replication.

Legionella pneumophila-induced PKCalpha-, MAPK-, and NF-kappaB-dependent COX-2 expression in human lung epithelium.

IFNbeta induction by influenza A virus is mediated by RIG-I which is regulated by the viral NS1 protein.

Comparative transcriptional profiling of the lung reveals shared and distinct features of Streptococcus pneumoniae and influenza A virus infection.

Adrenomedullin reduces vascular hyperpermeability and improves survival in rat septic shock.

The UspA1 protein of Moraxella catarrhalis induces CEACAM-1-dependent apoptosis in alveolar epithelial cells.

Role of platelet-activating factor in pneumolysin-induced acute lung injury.

Cell-specific interleukin-15 and interleukin-15 receptor subunit expression and regulation in pneumococcal pneumonia--comparison to chlamydial lung infection.

Proteomic characterization of the whole secretome of Legionella pneumophila and functional analysis of outer membrane vesicles.

Simvastatin reduces Chlamydophila pneumoniae-mediated histone modifications and gene expression in cultured human endothelial cells.

Rho-kinase and contractile apparatus proteins in murine airway hyperresponsiveness.

NAIP and Ipaf control Legionella pneumophila replication in human cells.

Histone acetylation and flagellin are essential for Legionella pneumophila-induced cytokine expression.

Beta-PIX and Rac1 GTPase mediate trafficking and negative regulation of NOD2.

Systemic use of the endolysin Cpl-1 rescues mice with fatal pneumococcal pneumonia.

Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia.

Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells.

Listeria monocytogenes-infected human peripheral blood mononuclear cells produce IL-1beta, depending on listeriolysin O and NLRP3.

TLR2- and nucleotide-binding oligomerization domain 2-dependent Krüppel-like factor 2 expression downregulates NF-kappa B-related gene expression.

Legionella pneumophila induces human beta defensin-3 in pulmonary cells.

Simvastatin attenuates ventilator-induced lung injury in mice.

Rac1 regulates the NLRP3 inflammasome which mediates IL-1beta production in Chlamydophila pneumoniae infected human mononuclear cells.

TLR9- and Src-dependent expression of Krueppel-like factor 4 controls interleukin-10 expression in pneumonia.

Systems biology and bioinformatics in aging research: a workshop report.

Asthma phenotyping, therapy, and prevention: what can we learn from systems biology?

MicroRNAs in the lung.

Benefits of whole body vibration training in patients hospitalised for COPD exacerbations - a randomized clinical trial.

Malignancy Associated MicroRNA Expression Changes in Canine Mammary Cancer of Different Malignancies.

Impaired TLR4 and HIF expression in cystic fibrosis bronchial epithelial cells downregulates hemeoxygenase-1 and alters iron homeostasis in vitro.

Therapy with plasma purified alpha1-antitrypsin (Prolastin®) induces time-dependent changes in plasma levels of MMP-9 and MPO.

Training in Systems Approaches for the Next Generation of Life Scientists and Medical Doctors.

Systems Medicine for Lung Diseases: Phenotypes and Precision Medicine in Cancer, Infection, and Allergy.

Third-Kind Encounters in Biomedicine: Immunology Meets Mathematics and Informatics to Become Quantitative and Predictive.

Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A.

MicroRNAs Constitute a Negative Feedback Loop in Streptococcus pneumoniae-Induced Macrophage Activation.

Legionella pneumophila-Derived Outer Membrane Vesicles Promote Bacterial Replication in Macrophages.

Genome-wide Chromatin Profiling of Legionella pneumophila-Infected Human Macrophages Reveals Activation of the Probacterial Host Factor TNFAIP2.

Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation.

An Interactive Macrophage Signal Transduction Map Facilitates Comparative Analyses of High-Throughput Data.