Carlijn V. C. Bouten

Predicting local cell deformations in engineered tissue constructs: a multilevel finite element approach.

In vitro models to study compressive strain-induced muscle cell damage.

The etiology of pressure ulcers: skin deep or muscle bound?

Monitoring local cell viability in engineered tissues: a fast, quantitative, and nondestructive approach.

Finite element model of mechanically induced collagen fiber synthesis and degradation in the aortic valve.

Inertial shear force and the impact on facilities for the International Space Station.

Review article: Tissue engineering of semilunar heart valves: current status and future developments.

Decreased mechanical stiffness in LMNA-/- cells is caused by defective nucleo-cytoskeletal integrity: implications for the development of laminopathies.

Anisotropic, three-dimensional deformation of single attached cells under compression.

Fibrin as a cell carrier in cardiovascular tissue engineering applications.

Viscoelastic properties of single attached cells under compression.

Improved prediction of the collagen fiber architecture in the aortic heart valve.

A structural constitutive model for collagenous cardiovascular tissues incorporating the angular fiber distribution.

Centrifuges and inertial shear forces.

Tissue engineering of human heart valve leaflets: a novel bioreactor for a strain-based conditioning approach.

Fluorescently labeled collagen binding proteins allow specific visualization of collagen in tissues and live cell culture.

An in vitro model system to study the damaging effects of prolonged mechanical loading of the epidermis.

Modeling the mechanics of tissue-engineered human heart valve leaflets.

Mechanical characterization of anisotropic planar biological soft tissues using large indentation: a computational feasibility study.

Autologous human tissue-engineered heart valves: prospects for systemic application.

The relative contributions of compression and hypoxia to development of muscle tissue damage: an in vitro study.

Remodelling of the angular collagen fiber distribution in cardiovascular tissues.

Temporal differences in the influence of ischemic factors and deformation on the metabolism of engineered skeletal muscle.

The role of collagen cross-links in biomechanical behavior of human aortic heart valve leaflets--relevance for tissue engineering.

High resolution imaging of collagen organisation and synthesis using a versatile collagen specific probe.

Effect of biomimetic conditions on mechanical and structural integrity of PGA/P4HB and electrospun PCL scaffolds.

Mechanical characterization of anisotropic planar biological soft tissues using finite indentation: experimental feasibility.

Effect of strain magnitude on the tissue properties of engineered cardiovascular constructs.

Effects of temperature and doxorubicin exposure on keratinocyte damage in vitro.

The influence of serum-free culture conditions on skeletal muscle differentiation in a tissue-engineered model.

Tailoring fiber diameter in electrospun poly(epsilon-caprolactone) scaffolds for optimal cellular infiltration in cardiovascular tissue engineering.

Stress related collagen ultrastructure in human aortic valves--implications for tissue engineering.

Intermittent straining accelerates the development of tissue properties in engineered heart valve tissue.

Straining mode-dependent collagen remodeling in engineered cardiovascular tissue.

Evaluation of a continuous quantification method of apoptosis and necrosis in tissue cultures.

Hypoxia induces near-native mechanical properties in engineered heart valve tissue.

Quantification of the temporal evolution of collagen orientation in mechanically conditioned engineered cardiovascular tissues.

Tissue engineering of heart valves: advances and current challenges.

Translating autologous heart valve tissue engineering from bench to bed.

Cytokine release in tissue-engineered epidermal equivalents after prolonged mechanical loading.

Platelet-lysate as an autologous alternative for fetal bovine serum in cardiovascular tissue engineering.

Tissue-engineered heart valves develop native-like collagen fiber architecture.

Environmental regulation of valvulogenesis: implications for tissue engineering.

Controlling matrix formation and cross-linking by hypoxia in cardiovascular tissue engineering.

Instructive materials for functional tissue engineering.

Substrates for cardiovascular tissue engineering.

Decreased mechanical properties of heart valve tissue constructs cultured in platelet lysate as compared to fetal bovine serum.

Sequential use of human-derived medium supplements favours cardiovascular tissue engineering.

Low oxygen concentrations impair tissue development in tissue-engineered cardiovascular constructs.

Variation in tissue outcome of ovine and human engineered heart valve constructs: relevance for tissue engineering.

Influence of substrate stiffness on circulating progenitor cell fate.

A mesofluidics-based test platform for systematic development of scaffolds for in situ cardiovascular tissue engineering.

Polymer-based scaffold designs for in situ vascular tissue engineering: controlling recruitment and differentiation behavior of endothelial colony forming cells.

Matrix production and remodeling capacity of cardiomyocyte progenitor cells during in vitro differentiation.

In situ heart valve tissue engineering: simple devices, smart materials, complex knowledge.

Strain-induced Collagen Organization at the Micro-level in Fibrin-based Engineered Tissue Constructs.

Then and now: hypes and hopes of regenerative medicine.

Understanding strain-induced collagen matrix development in engineered cardiovascular tissues from gene expression profiles.

Increased cardiac myocyte PDE5 levels in human and murine pressure overload hypertrophy contribute to adverse LV remodeling.

Computational model predicts cell orientation in response to a range of mechanical stimuli.

Matrix production and organization by endothelial colony forming cells in mechanically strained engineered tissue constructs.

Degree of scaffold degradation influences collagen (re)orientation in engineered tissues.

Computational and experimental investigation of local stress fiber orientation in uniaxially and biaxially constrained microtissues.

Differential response of endothelial and endothelial colony forming cells on electrospun scaffolds with distinct microfiber diameters.

Strain-dependent modulation of macrophage polarization within scaffolds.

Monocytic cells become less compressible but more deformable upon activation.

Cardiac patching and the regeneration of infarcted myocardium: where do we go from here?

Combining tissue repair and tissue engineering; bioactivating implantable cell-free vascular scaffolds.

Shear flow affects selective monocyte recruitment into MCP-1-loaded scaffolds.

Synergistic protein secretion by mesenchymal stromal cells seeded in 3D scaffolds and circulating leukocytes in physiological flow.

Colorful protein-based fluorescent probes for collagen imaging.

Extracellular vesicles: potential roles in regenerative medicine.

High-Throughput Screening Assay for the Identification of Compounds Enhancing Collagenous Extracellular Matrix Production by ATDC5 Cells.

Competition between cap and basal actin fiber orientation in cells subjected to contact guidance and cyclic strain.

The evolution of collagen fiber orientation in engineered cardiovascular tissues visualized by diffusion tensor imaging.

In Vivo Collagen Remodeling in the Vascular Wall of Decellularized Stented Tissue-Engineered Heart Valves.

In Situ Tissue Engineering of Functional Small-Diameter Blood Vessels by Host Circulating Cells Only.

Behavior of CMPCs in unidirectional constrained and stress-free 3D hydrogels.

Superior Tissue Evolution in Slow-Degrading Scaffolds for Valvular Tissue Engineering.

Early in-situ cellularization of a supramolecular vascular graft is modified by synthetic stromal cell-derived factor-1α derived peptides.

Development of Non-Cell Adhesive Vascular Grafts Using Supramolecular Building Blocks.

Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via Transforming Growth Factor-β Signaling.

Age-Dependent Changes in Geometry, Tissue Composition and Mechanical Properties of Fetal to Adult Cryopreserved Human Heart Valves.

Heading in the Right Direction: Understanding Cellular Orientation Responses to Complex Biophysical Environments.

A membrane-based microfluidic device for mechano-chemical cell manipulation.

Collagen Matrix Remodeling in Stented Pulmonary Arteries after Transapical Heart Valve Replacement.

Cardiomyocyte progenitor cell mechanoresponse unrevealed: strain avoidance and mechanosome development.

Intrinsic Cell Stress is Independent of Organization in Engineered Cell Sheets.

Conceptual model for early health technology assessment of current and novel heart valve interventions.

Cellular strain avoidance is mediated by a functional actin cap - observations in an -deficient cell model.

In situ heart valve tissue engineering using a bioresorbable elastomeric implant - From material design to 12 months follow-up in sheep.

Mimicking Cardiac Fibrosis in a Dish: Fibroblast Density Rather than Collagen Density Weakens Cardiomyocyte Function.

Robust Generation of Quiescent Porcine Valvular Interstitial Cell Cultures.

The Effects of Scaffold Remnants in Decellularized Tissue-Engineered Cardiovascular Constructs on the Recruitment of Blood Cells<sup/>.

Aortic calcified particles modulate valvular endothelial and interstitial cells.

A Bioreactor to Identify the Driving Mechanical Stimuli of Tissue Growth and Remodeling.

Vascular Mechanobiology: Towards Control of In Situ Regeneration.

Mechanically Robust Electrospun Hydrogel Scaffolds Crosslinked via Supramolecular Interactions.

Lmna knockout mouse embryonic fibroblasts are less contractile than their wild-type counterparts.

Cardiac Progenitor Cells and the Interplay with Their Microenvironment.

Biomaterial-driven in situ cardiovascular tissue engineering-a multi-disciplinary perspective.

Growth and remodeling play opposing roles during postnatal human heart valve development.

The Mechanical Contribution of Vimentin to Cellular Stress Generation.

Modulation of macrophage phenotype and protein secretion via heparin-IL-4 functionalized supramolecular elastomers.

An automated quantitative analysis of cell, nucleus and focal adhesion morphology.

Mechanosensitivity of Jagged-Notch signaling can induce a switch-type behavior in vascular homeostasis.

Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics.

A biomimetic microfluidic model to study signalling between endothelial and vascular smooth muscle cells under hemodynamic conditions.

Dual Electrospun Supramolecular Polymer Systems for Selective Cell Migration.

Decoupling the Effect of Shear Stress and Stretch on Tissue Growth and Remodeling in a Vascular Graft.

Can We Grow Valves Inside the Heart? Perspective on Material-based In Situ Heart Valve Tissue Engineering.

Host Response and Neo-Tissue Development during Resorption of a Fast Degrading Supramolecular Electrospun Arterial Scaffold.

Mesoscale substrate curvature overrules nanoscale contact guidance to direct bone marrow stromal cell migration.

Cyclic Strain Affects Macrophage Cytokine Secretion and Extracellular Matrix Turnover in Electrospun Scaffolds.

What Is the Potential of Tissue-Engineered Pulmonary Valves in Children?

Increased Cell Traction-Induced Prestress in Dynamically Cultured Microtissues.

Entropic Forces Drive Cellular Contact Guidance.

Macrophage-Driven Biomaterial Degradation Depends on Scaffold Microarchitecture.

Anti-fibrotic Effects of Cardiac Progenitor Cells in a 3D-Model of Human Cardiac Fibrosis.

The degradation and performance of electrospun supramolecular vascular scaffolds examined upon in vitro enzymatic exposure.

and Approaches Reveal Novel Insight Into the Ability of Epicardium-Derived Cells to Create Their Own Extracellular Environment.

Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress.

Functional peptide presentation on different hydrogen bonding biomaterials using supramolecular additives.

Hemodynamic loads distinctively impact the secretory profile of biomaterial-activated macrophages - implications for in situ vascular tissue engineering.

Fibrotic aortic valve disease after radiotherapy: an immunohistochemical study in breast cancer and lymphoma patients.

Triple-marker cardiac MRI detects sequential tissue changes of healing myocardium after a hydrogel-based therapy.

Early cost-utility analysis of tissue-engineered heart valves compared to bioprostheses in the aortic position in elderly patients.

Differential Leaflet Remodeling of Bone Marrow Cell Pre-Seeded Versus Nonseeded Bioresorbable Transcatheter Pulmonary Valve Replacements.

Publisher Correction: Triple-marker cardiac MRI detects sequential tissue changes of healing myocardium after a hydrogel-based therapy.

Cellular Geometry Sensing at Different Length Scales and its Implications for Scaffold Design.

Failure of decellularized porcine small intestinal submucosa as a heart valved conduit.

Pressure-induced collagen degradation in arterial tissue as a potential mechanism for degenerative arterial disease progression.

Human In Vitro Model Mimicking Material-Driven Vascular Regeneration Reveals How Cyclic Stretch and Shear Stress Differentially Modulate Inflammation and Matrix Deposition.

Imaging the In Vivo Degradation of Tissue Engineering Implants by Use of Supramolecular Radiopaque Biomaterials.

Cell-Perceived Substrate Curvature Dynamically Coordinates the Direction, Speed, and Persistence of Stromal Cell Migration.

Cellular Contact Guidance Emerges from Gap Avoidance.

Inconsistency in Graft Outcome of Bilayered Bioresorbable Supramolecular Arterial Scaffolds in Rats.

Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis.

Impact of Additives on Mechanical Properties of Supramolecular Electrospun Scaffolds.

Integrative Multi-Omics Analysis in Calcific Aortic Valve Disease Reveals a Link to the Formation of Amyloid-Like Deposits.

Transcatheter-Delivered Expandable Bioresorbable Polymeric Graft With Stenting Capacity Induces Vascular Regeneration.

Advanced Modeling to Study the Paradox of Mechanically Induced Cardiac Fibrosis.

In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves.

Methods to Model Cardiac Mechanobiology in Health and Disease.

A standard calculation methodology for human doubly labeled water studies.

Computationally guided in-vitro vascular growth model reveals causal link between flow oscillations and disorganized neotissue.

Protein Micropatterning in 2.5D: An Approach to Investigate Cellular Responses in Multi-Cue Environments.

A Brief History in Cardiac Regeneration, and How the Extra Cellular Matrix May Turn the Tide.

Bioprinting of kidney in vitro models: cells, biomaterials, and manufacturing techniques.

Mechanical Properties of Bioengineered Corneal Stroma.

An automated real-time microfluidic platform to probe single NK cell heterogeneity and cytotoxicity on-chip.

Energy compensation and adiposity in humans.

Physical activity and fat-free mass during growth and in later life.

Immuno-regenerative biomaterials for in situ cardiovascular tissue engineering - Do patient characteristics warrant precision engineering?

Renal Biology Driven Macro- and Microscale Design Strategies for Creating an Artificial Proximal Tubule Using Fiber-Based Technologies.

Distinct Effects of Heparin and Interleukin-4 Functionalization on Macrophage Polarization and In Situ Arterial Tissue Regeneration Using Resorbable Supramolecular Vascular Grafts in Rats.

Radiation Induces Valvular Interstitial Cell Calcific Response in an Model of Calcific Aortic Valve Disease.

Imparting Immunomodulatory Activity to Scaffolds via Biotin-Avidin Interactions.

Ultrastructural Characteristics of Myocardial Reperfusion Injury and Effect of Selective Intracoronary Hypothermia: An Observational Study in Isolated Beating Porcine Hearts.

Engineering tissue morphogenesis: taking it up a Notch.

Animal studies for the evaluation of in situ tissue-engineered vascular grafts - a systematic review, evidence map, and meta-analysis.

Changes in extracellular matrix in failing human non-ischemic and ischemic hearts with mechanical unloading.

Substrate Stiffness Determines the Establishment of Apical-Basal Polarization in Renal Epithelial Cells but Not in Tubuloid-Derived Cells.

In-vitro engineered human cerebral tissues mimic pathological circuit disturbances in 3D.

Pirfenidone Has Anti-fibrotic Effects in a Tissue-Engineered Model of Human Cardiac Fibrosis.

Cardiovascular Tissue Engineering and Regeneration: A Plead for Further Knowledge Convergence.

Engineered patterns of Notch ligands Jag1 and Dll4 elicit differential spatial control of endothelial sprouting.