A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

9.3K Views

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09:49 min

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April 24th, 2020

DOI :

10.3791/60477-v

April 24th, 2020

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9,318 Views

Maria Luisa Belli¹, Emilio Mezzenga¹, Valentina Di Iorio², Monica Celli³, Paola Caroli³, Elisabeth Canali³, Federica Matteucci³, Elisa Tardelli³, Ilaria Grassi³, Maddalena Sansovini³, Silvia Nicolini³, Stefano Severi³, Marta Cremonesi⁴, Mahila Ferrari⁵, Giovanni Paganelli³, Anna Sarnelli¹

¹Medical Physics Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy, ²Oncology Pharmacy, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy, ³Nuclear Medicine Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy, ⁴Radiation Research Unit, Istituto Europeo di Oncologia (IEO) IRCCS, Milano, Italy, ⁵Medical Physics Unit, Istituto Europeo di Oncologia (IEO) IRCCS, Milano, Italy

Kapitel

0:04

Introduction

1:24

Pre-Infusion Imaging: Transmission and Blank Image Acquisition

2:35

Post-Infusion Image Acquisition: Planar Image

3:21

Post-Infusion Image Acquisition: 3D SPECT/CT

3:51

Image Analysis

4:58

Blood Sample Measurements and Dosimetry Evaluation

5:50

Hybrid 2D+3D SCPET/CT Image Analysis

6:21

Adult Phantom Creation and Red Marrow Evaluation

7:50

Results: Representative Comparison of 2D, Hybrid 2D+3D, and 3D SPECT/CT Methods for Transient Intestine Uptake Overlap on Kidneys

8:35

Conclusion

Transkript

The method can be used in peptide-receptor radionuclide therapy and enable us to improve the accuracy of absorbed dose estimation in the presence of overlapping organs. The uptake distribution provided by the 3D SPECT/CT images is combined with th

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Zusammenfassung

This method estimates the absorbed dose of different structures for peptide-receptor-radionuclide-therapy (PRRT) with the possibility of avoiding organ overlap on 2D-projections. Serial whole-body planar images permit estimation of mean absorbed doses along the whole body, while the hybrid approach, combining planar images and 3D-SPECT/CT image, overcomes the limitations of structure overlapping.

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Keywords Peptide Receptor Radionuclide Therapy PRRT

Absorbed Dose Estimation

Radioligand Injection

Attenuation Correction

Image Acquisition

Effective Half Life