Our research is focused on physiological and pathological changes in perimenopausal women. In this study, we are trying to determine which pathophysiological alternations are related to FHC. Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.
Using this mouse model, we found that follicle-stimulating hormone, independent of aspirin, increases serum cholesterol levels. Moreover, blocking FSH signaling could effectively prevent hypocholesterolemia. This mouse model mimics the early stage of the menopause transition, characterized by elevated serum FSH levels and relatively stable estrogen levels.
The model has the advantages of being stable, low cost, and easy to operate, which is suitable for studies to explore the extra gonadal actions of FSH.
