Brandon J. Biesiadecki

Increased phosphorylation of tropomyosin, troponin I, and myosin light chain-2 after stretch in rabbit ventricular myocardium under physiological conditions.

A high-throughput solid-phase microplate protein-binding assay to investigate interactions between myofilament proteins.

Effects of increased preload on the force-frequency response and contractile kinetics in early stages of cardiac muscle hypertrophy.

AMP-activated protein kinase phosphorylates cardiac troponin I at Ser-150 to increase myofilament calcium sensitivity and blunt PKA-dependent function.

Engineered troponin C constructs correct disease-related cardiac myofilament calcium sensitivity.

Staurosporine inhibits frequency-dependent myofilament desensitization in intact rabbit cardiac trabeculae.

The rates of Ca2+ dissociation and cross-bridge detachment from ventricular myofibrils as reported by a fluorescent cardiac troponin C.

Advanced glycation end product cross-link breaker attenuates diabetes-induced cardiac dysfunction by improving sarcoplasmic reticulum calcium handling.

Effects of increased systolic Ca(2+) and β-adrenergic stimulation on Ca(2+) transient decline in NOS1 knockout cardiac myocytes.

Tropomyosin Ser-283 pseudo-phosphorylation slows myofibril relaxation.

Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides.

Protein kinase C phosphomimetics alter thin filament Ca2+ binding properties.

Desensitization of myofilaments to Ca2+ as a therapeutic target for hypertrophic cardiomyopathy with mutations in thin filament proteins.

Combined troponin I Ser-150 and Ser-23/24 phosphorylation sustains thin filament Ca(2+) sensitivity and accelerates deactivation in an acidic environment.

Upregulation of adenosine A1 receptors facilitates sinoatrial node dysfunction in chronic canine heart failure by exacerbating nodal conduction abnormalities revealed by novel dual-sided intramural optical mapping.

Cardiac troponin I tyrosine 26 phosphorylation decreases myofilament Ca2+ sensitivity and accelerates deactivation.

Obligatory role of neuronal nitric oxide synthase in the heart's antioxidant adaptation with exercise.

Dissociation of Calcium Transients and Force Development following a Change in Stimulation Frequency in Isolated Rabbit Myocardium.

Protein phosphatase 2A regulatory subunit B56α limits phosphatase activity in the heart.

Molecular Mapping of Sinoatrial Node HCN Channel Expression in the Human Heart.

Nucleotide and protein sequences for dog masticatory tropomyosin identify a novel Tpm4 gene product.

Should we treat heart failure with phosphatase inhibitors? Better to start at the end.

Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease.

Myofilament modulation of contraction.

The Need for Speed: Mice, Men, and Myocardial Kinetic Reserve.

Adenosine-Induced Atrial Fibrillation: Localized Reentrant Drivers in Lateral Right Atria due to Heterogeneous Expression of Adenosine A1 Receptors and GIRK4 Subunits in the Human Heart.

Myofilament Calcium Sensitivity: Role in Regulation of Cardiac Contraction and Relaxation.

Myofilament Calcium Sensitivity: Consequences of the Effective Concentration of Troponin I.

Tri-modal regulation of cardiac muscle relaxation; intracellular calcium decline, thin filament deactivation, and cross-bridge cycling kinetics.

Functional communication between PKC-targeted cardiac troponin I phosphorylation sites.

Secondary phosphorylation in myocytes expressing FLAG-tagged and non-tagged phospho-mimetic cardiac troponin I.

Assessment of PKA and PKC inhibitors on force and kinetics of non-failing and failing human myocardium.

3-Chlorodiphenylamine activates cardiac troponin by a mechanism distinct from bepridil or TFP.

Troponin I modulation of cardiac performance: Plasticity in the survival switch.

Current and Future Directions of Myofilament Regulation.

Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node.

Site-specific acetyl-mimetic modification of cardiac troponin I modulates myofilament relaxation and calcium sensitivity.

mutations in the tropomyosin binding region of TNT1 disrupt its role in contractile inhibition and stimulate cardiac dysfunction.

Heart Failure in Humans Reduces Contractile Force in Myocardium From Both Ventricles.

Post-translational modification patterns on β-myosin heavy chain are altered in ischemic and nonischemic human hearts.