Department of Pathology and Cell Biology,
The Taub Institute for Research on Alzheimer's Disease and the Aging Brain,
Department of Neurology
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Nedd2 is required for apoptosis after trophic factor withdrawal, but not superoxide dismutase (SOD1) downregulation, in sympathetic neurons and PC12 cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 1997 | Pubmed ID: 9045720
Multiple pathways of neuronal death induced by DNA-damaging agents, NGF deprivation, and oxidative stress.
The Journal of neuroscience : the official journal of the Society for Neuroscience Feb, 1998 | Pubmed ID: 9437005
Caspase-2 (Nedd-2) processing and death of trophic factor-deprived PC12 cells and sympathetic neurons occur independently of caspase-3 (CPP32)-like activity.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 1998 | Pubmed ID: 9801360
Caspase-2 mediates neuronal cell death induced by beta-amyloid.
The Journal of neuroscience : the official journal of the Society for Neuroscience Feb, 2000 | Pubmed ID: 10662829
Death in the balance: alternative participation of the caspase-2 and -9 pathways in neuronal death induced by nerve growth factor deprivation.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jul, 2001 | Pubmed ID: 11438576
Mechanisms of p75-mediated death of hippocampal neurons. Role of caspases.
The Journal of biological chemistry Sep, 2002 | Pubmed ID: 12097334
Caspases on the brain.
Journal of neuroscience research Jul, 2002 | Pubmed ID: 12111795
Divergence of the apoptotic pathways induced by 4-hydroxynonenal and amyloid beta-protein.
Neurobiology of aging Sep, 2004 | Pubmed ID: 15212831
Balancing neuronal death.
Journal of neuroscience research Oct, 2004 | Pubmed ID: 15372573
Highly efficient small interfering RNA delivery to primary mammalian neurons induces MicroRNA-like effects before mRNA degradation.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2004 | Pubmed ID: 15537872
Caspase function in neuronal death: delineation of the role of caspases in ischemia.
Current drug targets. CNS and neurological disorders Feb, 2005 | Pubmed ID: 15723613
Cell cycle molecules define a pathway required for neuron death in development and disease.
Biochimica et biophysica acta Apr, 2007 | Pubmed ID: 17229557
Bim is elevated in Alzheimer's disease neurons and is required for beta-amyloid-induced neuronal apoptosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jan, 2007 | Pubmed ID: 17251431
Mechanisms of neuronal death in disease: defining the models and the players.
The Biochemical journal Oct, 2008 | Pubmed ID: 18800967
Caspase-2: vestigial remnant or master regulator?
Science signaling , 2008 | Pubmed ID: 18812565
The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jan, 2009 | Pubmed ID: 19176810
Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jul, 2009 | Pubmed ID: 19587290
Cystatin C protects neuronal cells from amyloid-beta-induced toxicity.
Journal of Alzheimer's disease : JAD , 2010 | Pubmed ID: 20157244
Regulation of caspases in the nervous system implications for functions in health and disease.
Progress in molecular biology and translational science , 2011 | Pubmed ID: 21238939
Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory.
Annals of neurology May, 2011 | Pubmed ID: 21472769
Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 2011 | Pubmed ID: 21677173
Neuronal caspase 2 activity and function requires RAIDD, but not PIDD.
The Biochemical journal Jun, 2012 | Pubmed ID: 22515271
Caspase inhibitors: prospective therapies for stroke.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry Apr, 2013 | Pubmed ID: 22645109
Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection.
Molecular neurodegeneration , 2012 | Pubmed ID: 23217200
Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice.
Nature communications , 2013 | Pubmed ID: 23748737
Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death.
The Biochemical journal Oct, 2013 | Pubmed ID: 23815625
Combined suppression of CASP2 and CASP6 protects retinal ganglion cells from apoptosis and promotes axon regeneration through CNTF-mediated JAK/STAT signalling.
Brain : a journal of neurology Jun, 2014 | Pubmed ID: 24727569
Axonally synthesized ATF4 transmits a neurodegenerative signal across brain regions.
Cell Aug, 2014 | Pubmed ID: 25171414
Caspase-9 mediates photoreceptor death after blunt ocular trauma.
Investigative ophthalmology & visual science Oct, 2014 | Pubmed ID: 25190658
Caspases: therapeutic targets in neurologic disease.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics Jan, 2015 | Pubmed ID: 25339539
Mutations in CRADD Result in Reduced Caspase-2-Mediated Neuronal Apoptosis and Cause Megalencephaly with a Rare Lissencephaly Variant.
American journal of human genetics Nov, 2016 | Pubmed ID: 27773430
Caspase-2 and tau-a toxic partnership?
Nature medicine 11, 2016 | Pubmed ID: 27824824
Proneurotrophins Induce Apoptotic Neuronal Death After Controlled Cortical Impact Injury in Adult Mice.
ASN neuro Jan-Dec, 2020 | Pubmed ID: 32493127
Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion.
Nature communications 06, 2020 | Pubmed ID: 32576823
Author Correction: Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion.
Nature communications 07, 2020 | Pubmed ID: 32647109
Caspase-9: A Multimodal Therapeutic Target With Diverse Cellular Expression in Human Disease.
Frontiers in pharmacology , 2021 | Pubmed ID: 34305609
1Department of Pathology & Cell Biology; Vagelos College of Physicians and Surgeons, Columbia University,
2Department of Molecular Pharmacology and Therapeutics; Vagelos College of Physicians and Surgeons, Columbia University,
3Department of Neurology; Vagelos College of Physicians and Surgeons, Columbia University,
4The Taub Institute for Research on Alzheimer’s Disease and the Aging Brain; Vagelos College of Physicians and Surgeons, Columbia University
Crystal K. Colón Ortiz1,
Anna M. Potenski2,
Kendra V. Johnson1,
Claire W. Chen1,
Scott J. Snipas3,
Ying Y. Jean1,
Maria I. Avrutsky*,1,
Carol M. Troy*,1,4,5
1Department of Pathology & Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University,
2Department of Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University,
3NCI-designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute,
4Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University,
5The Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University
Claire W. Chen1,
Anna M. Potenski2,
Crystal K. Colón Ortiz1,
Maria I. Avrutsky*,1,
Carol M. Troy*,1,3,4
1Department of Pathology & Cell Biology; Vagelos College of Physicians and Surgeons, Columbia University,
2Department of Molecular Pharmacology and Therapeutics; Vagelos College of Physicians and Surgeons, Columbia University,
3Department of Neurology; Vagelos College of Physicians and Surgeons, Columbia University,
4The Taub Institute for Research on Alzheimer’s Disease and the Aging Brain; Vagelos College of Physicians and Surgeons, Columbia University
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