James B. Hurley

The core domain of a new retina specific RGS protein stimulates the GTPase activity of transducin in vitro.

A new form of inherited red-blindness identified in zebrafish.

Two amino acid substitutions convert a guanylyl cyclase, RetGC-1, into an adenylyl cyclase.

Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase.

Biochemical analysis of a dimerization domain mutation in RetGC-1 associated with dominant cone-rod dystrophy.

Folding and subunit assembly of photoreceptor peripherin/rds is mediated by determinants within the extracellular/intradiskal EC2 domain: implications for heterogeneous molecular pathologies.

Normal light response, photoreceptor integrity, and rhodopsin dephosphorylation in mice lacking both protein phosphatases with EF hands (PPEF-1 and PPEF-2).

Shedding light on adaptation.

Mass spectrometric analysis of the kinetics of in vivo rhodopsin phosphorylation.

Analysis of the visual cycle in cellular retinol-binding protein type I (CRBPI) knockout mice.

Light stimulates a transducin-independent increase of cytoplasmic Ca2+ and suppression of current in cones from the zebrafish mutant nof.

Acceleration of key reactions as a strategy to elucidate the rate-limiting chemistry underlying phototransduction inactivation.

AIPL1, a protein implicated in Leber's congenital amaurosis, interacts with and aids in processing of farnesylated proteins.

Visual pigment phosphorylation but not transducin translocation can contribute to light adaptation in zebrafish cones.

A zebrafish model for pyruvate dehydrogenase deficiency: rescue of neurological dysfunction and embryonic lethality using a ketogenic diet.

Functional analyses of mutant recessive GUCY2D alleles identified in Leber congenital amaurosis patients: protein domain comparisons and dominant negative effects.

Zebrafish rx3 and mab21l2 are required during eye morphogenesis.

Leber congenital amaurosis linked to AIPL1: a mouse model reveals destabilization of cGMP phosphodiesterase.

The zebrafish nrc mutant reveals a role for the polyphosphoinositide phosphatase synaptojanin 1 in cone photoreceptor ribbon anchoring.

Recoverin improves rod-mediated vision by enhancing signal transmission in the mouse retina.

Light-dependent redistribution of arrestin in vertebrate rods is an energy-independent process governed by protein-protein interactions.

Scotopic and photopic visual thresholds and spatial and temporal discrimination evaluated by behavior of mice in a water maze.

Biochemical function of the LCA linked protein, aryl hydrocarbon receptor interacting protein like-1 (AIPL1). Role of AIPL1 in retina.

Subunit dissociation and diffusion determine the subcellular localization of rod and cone transducins.

Regulation of arrestin binding by rhodopsin phosphorylation level.

Mechanism of light-induced translocation of arrestin and transducin in photoreceptors: interaction-restricted diffusion.

Loss of the Synaptic Vesicle Protein SV2B results in reduced neurotransmission and altered synaptic vesicle protein expression in the retina.

AIPL1, a protein associated with childhood blindness, interacts with alpha-subunit of rod phosphodiesterase (PDE6) and is essential for its proper assembly.

Arrestin competition influences the kinetics and variability of the single-photon responses of mammalian rod photoreceptors.

Relationships among visual cycle retinoids, rhodopsin phosphorylation, and phototransduction in mouse eyes during light and dark adaptation.

Optimal processing of photoreceptor signals is required to maximize behavioural sensitivity.

Flow of energy in the outer retina in darkness and in light.

PRE-1, a cis element sufficient to enhance cone- and rod- specific expression in differentiating zebrafish photoreceptors.

CTCF regulates ataxin-7 expression through promotion of a convergently transcribed, antisense noncoding RNA.

Roles of glucose in photoreceptor survival.

Na(V)1.1 channels are critical for intercellular communication in the suprachiasmatic nucleus and for normal circadian rhythms.

Guidelines for the use and interpretation of assays for monitoring autophagy.

Cytosolic reducing power preserves glutamate in retina.

Inhibition of mitochondrial pyruvate transport by zaprinast causes massive accumulation of aspartate at the expense of glutamate in the retina.

The retinal pigment epithelium utilizes fatty acids for ketogenesis.

Pyruvate kinase and aspartate-glutamate carrier distributions reveal key metabolic links between neurons and glia in retina.

Deregulated Myc requires MondoA/Mlx for metabolic reprogramming and tumorigenesis.

Glucose, lactate, and shuttling of metabolites in vertebrate retinas.

It's never too late to save a photoreceptor.

Probing Metabolism in the Intact Retina Using Stable Isotope Tracers.

Phototransduction Influences Metabolic Flux and Nucleotide Metabolism in Mouse Retina.

Deficient glucose and glutamine metabolism in knockout mice contributes to altered visual function.

Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration.

Reductive carboxylation is a major metabolic pathway in the retinal pigment epithelium.

Mitochondria Maintain Distinct Ca Pools in Cone Photoreceptors.

Human retinal pigment epithelial cells prefer proline as a nutrient and transport metabolic intermediates to the retinal side.

Warburg's vision.

Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye.

Pyruvate kinase M2 regulates photoreceptor structure, function, and viability.

How Excessive cGMP Impacts Metabolic Proteins in Retinas at the Onset of Degeneration.

Impact of euthanasia, dissection and postmortem delay on metabolic profile in mouse retina and RPE/choroid.

Loss of MPC1 reprograms retinal metabolism to impair visual function.

Increasing Ca in photoreceptor mitochondria alters metabolites, accelerates photoresponse recovery, and reveals adaptations to mitochondrial stress.

Retinal disease: How to use proteomics to speed up diagnosis and metabolomics to slow down degeneration.

Non-photopic and photopic visual cycles differentially regulate immediate, early, and late phases of cone photoreceptor-mediated vision.

Succinate Can Shuttle Reducing Power from the Hypoxic Retina to the O-Rich Pigment Epithelium.

Mitochondrial Calcium Uniporter (MCU) deficiency reveals an alternate path for Ca uptake in photoreceptor mitochondria.

Daily mitochondrial dynamics in cone photoreceptors.

Absence of retbindin blocks glycolytic flux, disrupts metabolic homeostasis, and leads to photoreceptor degeneration.

Effect of selectively knocking down key metabolic genes in Müller glia on photoreceptor health.

Mitochondria: The Retina's Achilles' Heel in AMD.

Retina Metabolism and Metabolism in the Pigmented Epithelium: A Busy Intersection.

Fluidics system for resolving concentration-dependent effects of dissolved gases on tissue metabolism.

An Analysis of Metabolic Changes in the Retina and Retinal Pigment Epithelium of Aging Mice.

Extracellular matrix dysfunction in Sorsby patient-derived retinal pigment epithelium.

Monocarboxylate Transporter 1 (MCT1) Mediates Succinate Export in the Retina.

Succinate metabolism in the retinal pigment epithelium uncouples respiration from ATP synthesis.

Transducin-Deficient Rod Photoreceptors Evaluated With Optical Coherence Tomography and Oxygen Consumption Rate Energy Biomarkers.

The multi-tissue landscape of somatic mtDNA mutations indicates tissue-specific accumulation and removal in aging.

Proline provides a nitrogen source in the retinal pigment epithelium to synthesize and export amino acids for the neural retina.

Aerobic Glycolysis in Photoreceptors Supports Energy Demand in the Absence of Mitochondrial Coupling.