Department of Anatomy & Structural Biology,
Gruss-Lipper Biophotonics Center,
Integrated Imaging Program,
Gruss-Lipper Biophotonics Center Integrated Imaging Program,
Department of Anatomy and Structural Biology
John S. Condeelis has not added Biography.
If you are John S. Condeelis and would like to personalize this page please email our Author Liaison for assistance.
A new strategy for caging proteins regulated by kinases.
Journal of the American Chemical Society Mar, 2002 | Pubmed ID: 11890784
Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling.
Cancer research Nov, 2002 | Pubmed ID: 12414658
GFP expression in the mammary gland for imaging of mammary tumor cells in transgenic mice.
Cancer research Dec, 2002 | Pubmed ID: 12499251
Gene expression analysis on small numbers of invasive cells collected by chemotaxis from primary mammary tumors of the mouse.
BMC biotechnology Aug, 2003 | Pubmed ID: 12914671
Cofilin promotes actin polymerization and defines the direction of cell motility.
Science (New York, N.Y.) Apr, 2004 | Pubmed ID: 15118165
Over-expression of the p110beta but not p110alpha isoform of PI 3-kinase inhibits motility in breast cancer cells.
Cell motility and the cytoskeleton Nov, 2004 | Pubmed ID: 15468162
Breast cancer cells isolated by chemotaxis from primary tumors show increased survival and resistance to chemotherapy.
Cancer research Nov, 2004 | Pubmed ID: 15520165
Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors.
Cancer research Dec, 2004 | Pubmed ID: 15574765
Tumor cells caught in the act of invading: their strategy for enhanced cell motility.
Trends in cell biology Mar, 2005 | Pubmed ID: 15752977
Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop.
Cancer research Jun, 2005 | Pubmed ID: 15958574
The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumors.
The Journal of cell biology May, 2006 | Pubmed ID: 16651380
Initiation of cofilin activity in response to EGF is uncoupled from cofilin phosphorylation and dephosphorylation in carcinoma cells.
Journal of cell science Jul, 2006 | Pubmed ID: 16803871
ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo.
Current biology : CB Aug, 2006 | Pubmed ID: 16890527
Molecular cloning of hMena (ENAH) and its splice variant hMena+11a: epidermal growth factor increases their expression and stimulates hMena+11a phosphorylation in breast cancer cell lines.
Cancer research Mar, 2007 | Pubmed ID: 17363586
Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors.
Cancer research Apr, 2007 | Pubmed ID: 17440055
The distinct roles of Ras and Rac in PI 3-kinase-dependent protrusion during EGF-stimulated cell migration.
Journal of cell science Sep, 2007 | Pubmed ID: 17698922
Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells.
Journal of cell science Oct, 2007 | Pubmed ID: 17855387
ZBP1 enhances cell polarity and reduces chemotaxis.
Journal of cell science Sep, 2007 | Pubmed ID: 17878234
EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cells.
The Journal of cell biology Dec, 2007 | Pubmed ID: 18086920
RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells.
Experimental cell research Apr, 2008 | Pubmed ID: 18316075
Mechanisms and cellular roles of local protein synthesis in mammalian cells.
Current opinion in cell biology Apr, 2008 | Pubmed ID: 18378131
Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo.
Clinical & experimental metastasis , 2009 | Pubmed ID: 18985426
A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis.
Developmental cell Dec, 2008 | Pubmed ID: 19081071
Tumor microenvironment of metastasis in human breast carcinoma: a potential prognostic marker linked to hematogenous dissemination.
Clinical cancer research : an official journal of the American Association for Cancer Research Apr, 2009 | Pubmed ID: 19318480
Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase.
Cancer research Dec, 2009 | Pubmed ID: 19903845
Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor.
Cancer research Dec, 2009 | Pubmed ID: 19934330
Gene expression analysis of macrophages that facilitate tumor invasion supports a role for Wnt-signaling in mediating their activity in primary mammary tumors.
Journal of immunology (Baltimore, Md. : 1950) Jan, 2010 | Pubmed ID: 20018620
AACR special conference on epithelial-mesenchymal transition and cancer progression and treatment.
Cancer research Oct, 2010 | Pubmed ID: 20823151
A new chemotaxis device for cell migration studies.
Integrative biology : quantitative biosciences from nano to macro Nov, 2010 | Pubmed ID: 20938544
Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumors.
Breast cancer research : BCR , 2010 | Pubmed ID: 21108830
Imaging real-time gene expression in Mammalian cells with single-transcript resolution.
CSH protocols , 2007 | Pubmed ID: 21356977
Imaging real-time gene expression in living yeast.
CSH protocols , 2007 | Pubmed ID: 21356978
Imaging real-time gene expression in living systems with single-transcript resolution: image analysis of single mRNA transcripts.
CSH protocols , 2007 | Pubmed ID: 21356979
Imaging Real-Time Gene Expression in Living Systems with Single-Transcript Resolution: Single mRNA Particle Tracking with ImageJ-Based Analysis.
CSH protocols , 2007 | Pubmed ID: 21356980
Imaging real-time gene expression in living systems with single-transcript resolution: construct design and imaging system setup.
CSH protocols , 2007 | Pubmed ID: 21356986
Mena invasive (Mena(INV)) and Mena11a isoforms play distinct roles in breast cancer cell cohesion and association with TMEM.
Clinical & experimental metastasis Aug, 2011 | Pubmed ID: 21484349
Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer.
Journal of cell science Jul, 2011 | Pubmed ID: 21670198
Chemotaxis in cancer.
Nature reviews. Cancer Aug, 2011 | Pubmed ID: 21779009
A photoswitchable orange-to-far-red fluorescent protein, PSmOrange.
Nature methods Sep, 2011 | Pubmed ID: 21804536
An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype.
PLoS genetics Aug, 2011 | Pubmed ID: 21876675
Opposing roles of CXCR4 and CXCR7 in breast cancer metastasis.
Breast cancer research : BCR Dec, 2011 | Pubmed ID: 22152016
Correlated Immunohistochemical and Cytological Assays for the Prediction of Hematogenous Dissemination of Breast Cancer.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society Jan, 2012 | Pubmed ID: 22215635
Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2012 | Pubmed ID: 22869695
A FRET-facilitated photoswitching using an orange fluorescent protein with the fast photoconversion kinetics.
Journal of the American Chemical Society Sep, 2012 | Pubmed ID: 22900938
Quantitative assessment of invasive mena isoforms (Menacalc) as an independent prognostic marker in breast cancer.
Breast cancer research : BCR , 2012 | Pubmed ID: 22971274
Selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients.
Breast cancer research : BCR , 2012 | Pubmed ID: 23113900
Dysregulation of PAD4-mediated citrullination of nuclear GSK3β activates TGF-β signaling and induces epithelial-to-mesenchymal transition in breast cancer cells.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2013 | Pubmed ID: 23818587
Wiskott-Aldrich syndrome protein regulates leukocyte-dependent breast cancer metastasis.
Cell reports Aug, 2013 | Pubmed ID: 23911287
Filamin A interacting protein 1-like inhibits WNT signaling and MMP expression to suppress cancer cell invasion and metastasis.
International journal of cancer Jul, 2014 | Pubmed ID: 24327474
Reconstitution of in vivo macrophage-tumor cell pairing and streaming motility on one-dimensional micro-patterned substrates.
Intravital Jul, 2012 | Pubmed ID: 24634804
Spatial regulation of tumor cell protrusions by RhoC.
Cell adhesion & migration , 2014 | Pubmed ID: 24642482
Invadopodia in context.
Cell adhesion & migration , 2014 | Pubmed ID: 24713806
Tumor microenvironment of metastasis and risk of distant metastasis of breast cancer.
Journal of the National Cancer Institute Aug, 2014 | Pubmed ID: 24895374
Metastatic cells: moving onco-targets.
Oncotarget Jun, 2014 | Pubmed ID: 24907202
An in vitro one-dimensional assay to study growth factor-regulated tumor cell-macrophage interaction.
Methods in molecular biology (Clifton, N.J.) , 2014 | Pubmed ID: 24908299
Intravital multiphoton imaging reveals multicellular streaming as a crucial component of in vivo cell migration in human breast tumors.
Intravital Apr, 2013 | Pubmed ID: 25013744
Development path and current status of the NANIVID: a new device for cancer cell studies.
Journal of micro/nanolithography, MEMS, and MOEMS : JM3 Mar, 2012 | Pubmed ID: 25419258
Invasive breast carcinoma cells from patients exhibit MenaINV- and macrophage-dependent transendothelial migration.
Science signaling Nov, 2014 | Pubmed ID: 25429076
Menacalc, a quantitative method of metastasis assessment, as a prognostic marker for axillary node-negative breast cancer.
BMC cancer , 2015 | Pubmed ID: 26112005
Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA.
Cancer discovery Sep, 2015 | Pubmed ID: 26269515
PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena.
Molecular biology of the cell Nov, 2015 | Pubmed ID: 26337385
Characterization of the expression of the pro-metastatic Mena(INV) isoform during breast tumor progression.
Clinical & experimental metastasis Mar, 2016 | Pubmed ID: 26680363
3-D individual cell based computational modeling of tumor cell-macrophage paracrine signaling mediated by EGF and CSF-1 gradients.
Integrative biology : quantitative biosciences from nano to macro Jan, 2016 | Pubmed ID: 26686751
GPCR Signaling Mediates Tumor Metastasis via PI3Kβ.
Cancer research May, 2016 | Pubmed ID: 27013201
Signatures of breast cancer metastasis at a glance.
Journal of cell science May, 2016 | Pubmed ID: 27084578
Black race and distant recurrence after neoadjuvant or adjuvant chemotherapy in breast cancer.
Clinical & experimental metastasis 10, 2018 | Pubmed ID: 30136072
Validation of an Automated Quantitative Digital Pathology Approach for Scoring TMEM, a Prognostic Biomarker for Metastasis.
Cancers Mar, 2020 | Pubmed ID: 32244564
Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells.
Nature communications Feb, 2022 | Pubmed ID: 35110548
Combining TMEM Doorway Score and Mena Score Improves the Prediction of Distant Recurrence Risk in HR+/HER2- Breast Cancer Patients.
Cancers Apr, 2022 | Pubmed ID: 35565297
Racial disparity in distant recurrence-free survival in patients with localized breast cancer: A pooled analysis of National Surgical Adjuvant Breast and Bowel Project trials.
Cancer Jul, 2022 | Pubmed ID: 35578919
Assessment of MRI to estimate metastatic dissemination risk and prometastatic effects of chemotherapy.
NPJ breast cancer Sep, 2022 | Pubmed ID: 36056005
Interleukin 4 Controls the Pro-Tumoral Role of Macrophages in Mammary Cancer Pulmonary Metastasis in Mice.
Cancers Sep, 2022 | Pubmed ID: 36077870
Intravital imaging to study cancer progression and metastasis.
Nature reviews. Cancer Jan, 2023 | Pubmed ID: 36385560
Cooperative NF-κB and Notch1 signaling promotes macrophage-mediated MenaINV expression in breast cancer.
Breast cancer research : BCR Apr, 2023 | Pubmed ID: 37024946
Macrophages Promote Tumor Cell Extravasation across an Endothelial Barrier through Thin Membranous Connections.
Cancers Mar, 2023 | Pubmed ID: 37046751
Racial disparity in tumor microenvironment and distant recurrence in residual breast cancer after neoadjuvant chemotherapy.
NPJ breast cancer Jun, 2023 | Pubmed ID: 37311792
Carolina Rodriguez-Tirado1,
Takanori Kitamura5,
Yu Kato1,2,
Jeffery W. Pollard1,2,5,
John S. Condeelis3,4,
David Entenberg3,4
1Department of Developmental and Molecular Biology, Albert Einstein College of Medicine,
2Department of Obstetrics/Gynecology and Woman’s Health, Albert Einstein College of Medicine,
3Department of Anatomy & Structural Biology, Albert Einstein College of Medicine,
4Gruss-Lipper Biophotonics Center Integrated Imaging Program, Albert Einstein College of Medicine,
5Medical Research Council Centre for Reproductive Health, Queen’s Medical Research Institute, University of Edinburgh
George S. Karagiannis1,2,3,
Jessica M. Pastoriza1,2,4,
Lucia Borriello1,2,
Rojin Jafari1,2,
Anouchka Coste1,2,4,
John S. Condeelis1,2,3,4,
Maja H. Oktay1,2,3,5,
David Entenberg1,2,3
1Department of Anatomy and Structural Biology, Albert Einstein College of Medicine,
2Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine,
3Integrated Imaging Program, Albert Einstein College of Medicine,
4Department of Surgery, Montefiore Medical Center,
5Department of Pathology, Montefiore Medical Center
Madeline Friedman-DeLuca1,2,
Prachiben P. Patel1,2,
Burcu Karadal-Ferrena1,2,
Nicole D. Barth1,2,
Camille L. Duran1,2,
Xianjun Ye1,2,3,
Michael Papanicolaou2,4,
John S. Condeelis2,3,4,5,6,7,
Maja H. Oktay1,2,3,5,6,7,
Lucia Borriello*,1,2,8,
David Entenberg*,1,2,3,5,6
1Department of Pathology, Albert Einstein College of Medicine/Montefiore Medical Center,
2Cancer Dormancy and Tumor Microenvironment Institute, Albert Einstein College of Medicine/Montefiore Medical Center,
3Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine/Montefiore Medical Center,
4Department of Cell Biology, Albert Einstein College of Medicine/Montefiore Medical Center,
5Montefiore Einstein Cancer Center, Albert Einstein College of Medicine/Montefiore Medical Center,
6Integrated Imaging Program for Cancer Research, Albert Einstein College of Medicine/Montefiore Medical Center,
7Department of Surgery, Albert Einstein College of Medicine/Montefiore Medical Center,
8Department of Cancer and Cellular Biology, Lewis Katz School of Medicine, Fox Chase Cancer Center
ABOUT JoVE
Copyright © 2024 MyJoVE Corporation. All rights reserved