Mary K. Estes

The 3' end of Norwalk virus mRNA contains determinants that regulate the expression and stability of the viral capsid protein VP1: a novel function for the VP2 protein.

Rotavirus antigenaemia and viraemia: a common event?

The reversible condensation and expansion of the rotavirus genome.

Trypsin cleavage stabilizes the rotavirus VP4 spike.

Recombinant Norwalk virus-like particles administered intranasally to mice induce systemic and mucosal (fecal and vaginal) immune responses.

Differential infection of polarized epithelial cell lines by sialic acid-dependent and sialic acid-independent rotavirus strains.

Group A rotavirus infection and age-dependent diarrheal disease in rats: a new animal model to study the pathophysiology of rotavirus infection.

VLA-2 (alpha2beta1) integrin promotes rotavirus entry into cells but is not necessary for rotavirus attachment.

Structural requirements for the assembly of Norwalk virus-like particles.

Initial interaction of rotavirus strains with N-acetylneuraminic (sialic) acid residues on the cell surface correlates with VP4 genotype, not species of origin.

Norwalk virus infection and disease is associated with ABO histo-blood group type.

Sequence analysis of the VP4, VP6, VP7, and NSP4 gene products of the bovine rotavirus WC3.

Cross-reactivity among several recombinant calicivirus virus-like particles (VLPs) with monoclonal antibodies obtained from mice immunized orally with one type of VLP.

Norwalk virus-like particle hemagglutination by binding to h histo-blood group antigens.

Two nonoverlapping domains on the Norwalk virus open reading frame 3 (ORF3) protein are involved in the formation of the phosphorylated 35K protein and in ORF3-capsid protein interactions.

Immunogenicity and protective efficacy of rotavirus 2/6-virus-like particles produced by a dual baculovirus expression vector and administered intramuscularly, intranasally, or orally to mice.

Laboratory efforts to cultivate noroviruses.

Inter- and intragenus structural variations in caliciviruses and their functional implications.

Norovirus disease: changing epidemiology and host susceptibility factors.

The VP7 outer capsid protein of rotavirus induces polyclonal B-cell activation.

Diagnosis of norwalk virus infection by indirect enzyme immunoassay detection of salivary antibodies to recombinant norwalk virus antigen.

Evolutionary trace residues in noroviruses: importance in receptor binding, antigenicity, virion assembly, and strain diversity.

B-cell and T-cell immune responses to experimental Helicobacter pylori infection in humans.

Intestinal TSH production is localized in crypt enterocytes and in villus 'hotblocks' and is coupled to IL-7 production: evidence for involvement of TSH during acute enteric virus infection.

Identification of Genogroup I and Genogroup II broadly reactive epitopes on the norovirus capsid.

pH-induced conformational change of the rotavirus VP4 spike: implications for cell entry and antibody neutralization.

Replication and packaging of Norwalk virus RNA in cultured mammalian cells.

Norwalk virus infection associates with secretor status genotyped from sera.

Host, viral, and vaccine factors that determine protective efficacy induced by rotavirus and virus-like particles (VLPs).

Evaluation of serum antibody responses against the rotavirus nonstructural protein NSP4 in children after rhesus rotavirus tetravalent vaccination or natural infection.

Rotavirus viremia and extraintestinal viral infection in the neonatal rat model.

X-ray crystallographic structure of the Norwalk virus protease at 1.5-A resolution.

X-ray structure of a native calicivirus: structural insights into antigenic diversity and host specificity.

Norwalk virus-specific binding to oyster digestive tissues.

Comparative study of the epidemiology of rotavirus in children from a community-based birth cohort and a hospital in South India.

The epidemiologic and clinical importance of norovirus infection.

Cryoelectron microscopy structures of rotavirus NSP2-NSP5 and NSP2-RNA complexes: implications for genome replication.

Noroviruses everywhere: has something changed?

Geographic information systems and genotyping in identification of rotavirus G12 infections in residents of an urban slum with subsequent detection in hospitalized children: emergence of G12 genotype in South India.

Expression of rotavirus NSP4 alters the actin network organization through the actin remodeling protein cofilin.

Neonatal infection with G10P[11] rotavirus did not confer protection against subsequent rotavirus infection in a community cohort in Vellore, South India.

Norwalk virus RNA is infectious in mammalian cells.

Epitope mapping and use of epitope-specific antisera to characterize the VP5* binding site in rotavirus SA11 NSP4.

Differential requirements for T cells in viruslike particle- and rotavirus-induced protective immunity.

Integrins alpha1beta1 and alpha2beta1 are receptors for the rotavirus enterotoxin.

Atomic resolution structural characterization of recognition of histo-blood group antigens by Norwalk virus.

Recommendations for the classification of group A rotaviruses using all 11 genomic RNA segments.

Norwalk virus shedding after experimental human infection.

Rotavirus architecture at subnanometer resolution.

Rotavirus vaccines and pathogenesis: 2008.

Rotaviruses: from pathogenesis to vaccination.

Norovirus gastroenteritis.

Burden of illness in the first 3 years of life in an Indian slum.

Vaccine-acquired rotavirus in infants with severe combined immunodeficiency.

Rotavirus enterotoxin NSP4 has mucosal adjuvant properties.

Norwalk virus assembly and stability monitored by mass spectrometry.

Rotavirus structural proteins and dsRNA are required for the human primary plasmacytoid dendritic cell IFNalpha response.

Intestinal epithelia activate anti-viral signaling via intracellular sensing of rotavirus structural components.

Norwalk virus does not replicate in human macrophages or dendritic cells derived from the peripheral blood of susceptible humans.

An inside job: subversion of the host secretory pathway by intestinal pathogens.

Serological correlate of protection against norovirus-induced gastroenteritis.

Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal.

Adsorption and aggregation properties of norovirus GI and GII virus-like particles demonstrate differing responses to solution chemistry.

Rotavirus disrupts calcium homeostasis by NSP4 viroporin activity.

Reconciliation of rotavirus temperature-sensitive mutant collections and assignment of reassortment groups D, J, and K to genome segments.

Serological responses to experimental Norwalk virus infection measured using a quantitative duplex time-resolved fluorescence immunoassay.

Uniformity of rotavirus strain nomenclature proposed by the Rotavirus Classification Working Group (RCWG).

Golgi localization of ERManI defines spatial separation of the mammalian glycoprotein quality control system.

Structural analysis of histo-blood group antigen binding specificity in a norovirus GII.4 epidemic variant: implications for epochal evolution.

Osteopontin upregulation in rotavirus-induced murine biliary atresia requires replicating virus but is not necessary for development of biliary atresia.

Protective effect of natural rotavirus infection in an Indian birth cohort.

Prestress strengthens the shell of Norwalk virus nanoparticles.

Rotavirus and biliary atresia: can causation be proven?

Norovirus vaccine against experimental human Norwalk Virus illness.

Serum hemagglutination inhibition activity correlates with protection from gastroenteritis in persons infected with Norwalk virus.

Genetic divergence of rotavirus nonstructural protein 4 results in distinct serogroup-specific viroporin activity and intracellular punctate structure morphologies.

Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen.

Stem cell-derived human intestinal organoids as an infection model for rotaviruses.

Rotavirus non-structural proteins: structure and function.

Crystallographic Analysis of Rotavirus NSP2-RNA Complex Reveals Specific Recognition of 5' GG Sequence for RTPase Activity.

Secretory pathway antagonism by calicivirus homologues of Norwalk virus nonstructural protein p22 is restricted to noroviruses.

Antibody responses to norovirus genogroup GI.1 and GII.4 proteases in volunteers administered Norwalk virus.

Norovirus vaccine development: next steps.

A time-resolved immunoassay to measure serum antibodies to the rotavirus VP6 capsid protein.

Autophagy hijacked through viroporin-activated calcium/calmodulin-dependent kinase kinase-β signaling is required for rotavirus replication.

Structural basis of substrate specificity and protease inhibition in Norwalk virus.

Norwalk Virus Minor Capsid Protein VP2 Associates within the VP1 Shell Domain.

Viroporin-mediated calcium-activated autophagy.

Identification and characterization of a peptide affinity reagent for detection of noroviruses in clinical samples.

Exposure to human and bovine noroviruses in a birth cohort in southern India from 2002 to 2006.

The VP8* domain of neonatal rotavirus strain G10P[11] binds to type II precursor glycans.

Lack of norovirus replication and histo-blood group antigen expression in 3-dimensional intestinal epithelial cells.

Noroviruses: The Most Common Pediatric Viral Enteric Pathogen at a Large University Hospital After Introduction of Rotavirus Vaccination.

Prevention of cholestasis in the murine rotavirus-induced biliary atresia model using passive immunization and nonreplicating virus-like particles.

Activation of the endoplasmic reticulum calcium sensor STIM1 and store-operated calcium entry by rotavirus requires NSP4 viroporin activity.

A novel form of rotavirus NSP2 and phosphorylation-dependent NSP2-NSP5 interactions are associated with viroplasm assembly.

Epidemiology of human noroviruses and updates on vaccine development.

Synthesis, Activity and Structure-Activity Relationship of Noroviral Protease Inhibitors.

Determination of the 50% human infectious dose for Norwalk virus.

Seroepidemiology of norovirus-associated travelers' diarrhea.

Human enteroids: preclinical models of non-inflammatory diarrhea.

Structural analysis of determinants of histo-blood group antigen binding specificity in genogroup I noroviruses.

Human enteroids as an ex-vivo model of host-pathogen interactions in the gastrointestinal tract.

Identification of human single-chain antibodies with broad reactivity for noroviruses.

Development of a Gaussia luciferase-based human norovirus protease reporter system: cell type-specific profile of Norwalk virus protease precursors and evaluation of inhibitors.

Reply to Kirby et al.

Human milk contains novel glycans that are potential decoy receptors for neonatal rotaviruses.

Structural characterization by multistage mass spectrometry (MSn) of human milk glycans recognized by human rotaviruses.

Structural basis of glycan interaction in gastroenteric viral pathogens.

Probing the sites of interactions of rotaviral proteins involved in replication.

Plasmid-based human norovirus reverse genetics system produces reporter-tagged progeny virus containing infectious genomic RNA.

Norovirus vaccine against experimental human GII.4 virus illness: a challenge study in healthy adults.

Structural plasticity of the coiled-coil domain of rotavirus NSP4.

Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18.

Mapping broadly reactive norovirus genogroup I and II monoclonal antibodies.

Characterization of cross-reactive norovirus-specific monoclonal antibodies.

Experimental human infection with Norwalk virus elicits a surrogate neutralizing antibody response with cross-genogroup activity.

Mucosal and Cellular Immune Responses to Norwalk Virus.

Noroviruses as a Cause of Diarrhea in Immunocompromised Pediatric Hematopoietic Stem Cell and Solid Organ Transplant Recipients.

Sensitive detection of norovirus using phage nanoparticle reporters in lateral-flow assay.

Women in Science: Hints for Success.

Serological Correlates of Protection against a GII.4 Norovirus.

Structural basis of glycan specificity in neonate-specific bovine-human reassortant rotavirus.

Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology.

Norovirus Antigen Detection with a Combination of Monoclonal and Single-Chain Antibodies.

Serological Responses to a Norovirus Nonstructural Fusion Protein after Vaccination and Infection.

Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology.

Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology.

Enterohemorrhagic reduce mucus and intermicrovillar bridges in human stem cell-derived colonoids.

Pathophysiological Consequences of Calcium-Conducting Viroporins.

Correlates of Protection against Norovirus Infection and Disease-Where Are We Now, Where Do We Go?

Rotavirus Serum IgA Immune Response in Children Receiving Rotarix Coadministered With bOPV or IPV.

Norovirus Gastroenteritis in a Birth Cohort in Southern India.

Antiviral targets of human noroviruses.

Physiologically relevant human tissue models for infectious diseases.

Frequent Use of the IgA Isotype in Human B Cells Encoding Potent Norovirus-Specific Monoclonal Antibodies That Block HBGA Binding.

Detection of human norovirus in intestinal biopsies from immunocompromised transplant patients.

Replication of Human Norovirus RNA in Mammalian Cells Reveals Lack of Interferon Response.

Correction for Hesse et al., Serological Responses to a Norovirus Nonstructural Fusion Protein after Vaccination and Infection.

Replication of human noroviruses in stem cell-derived human enteroids.

Editorial overview: Viruses and cell metabolism.

Structural basis for norovirus neutralization by an HBGA blocking human IgA antibody.

Human mini-guts: new insights into intestinal physiology and host-pathogen interactions.

Deep sequencing of phage-displayed peptide libraries reveals sequence motif that detects norovirus.

A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection.

Diversity in Rotavirus-Host Glycan Interactions: A "Sweet" Spectrum.

Identification and Characterization of Single-Chain Antibodies that Specifically Bind GI Noroviruses.

The Contributions of Human Mini-Intestines to the Study of Intestinal Physiology and Pathophysiology.

B-Cell Responses to Intramuscular Administration of a Bivalent Virus-Like Particle Human Norovirus Vaccine.

Human Intestinal Enteroids: New Models to Study Gastrointestinal Virus Infections.

Human Sera Collected between 1979 and 2010 Possess Blocking-Antibody Titers to Pandemic GII.4 Noroviruses Isolated over Three Decades.

Gastrointestinal microphysiological systems.

Structural features of glycan recognition among viral pathogens.

Milk Oligosaccharides Inhibit Human Rotavirus Infectivity in MA104 Cells.

Prospects and Challenges in the Development of a Norovirus Vaccine.

Role for FimH in Extraintestinal Pathogenic Escherichia coli Invasion and Translocation through the Intestinal Epithelium.

Rotavirus infection.

In vitro enteroid-derived three-dimensional tissue model of human small intestinal epithelium with innate immune responses.

Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation.

Novel Segment- and Host-Specific Patterns of Enteroaggregative Adherence to Human Intestinal Enteroids.

Human organoid cultures: transformative new tools for human virus studies.

Engineered Human Gastrointestinal Cultures to Study the Microbiome and Infectious Diseases.

Glycan recognition in globally dominant human rotaviruses.

Human Norovirus Replication in Human Intestinal Enteroids as Model to Evaluate Virus Inactivation.

Viral gastroenteritis.

Human noroviruses: recent advances in a 50-year history.

Bile acids target proteolipid nano-assemblies of EGFR and phosphatidic acid in the plasma membrane for stimulation of MAPK signaling.

Human Monoclonal Antibodies That Neutralize Pandemic GII.4 Noroviruses.

Human milk oligosaccharides, milk microbiome and infant gut microbiome modulate neonatal rotavirus infection.

Phosphorylation cascade regulates the formation and maturation of rotaviral replication factories.

GII.4 Norovirus Protease Shows pH-Sensitive Proteolysis with a Unique Arg-His Pairing in the Catalytic Site.

Changes of tight junction and interleukin-8 expression using a human gastroid monolayer model of Helicobacter pylori infection.

Human Intestinal Enteroids With Inducible Neurogenin-3 Expression as a Novel Model of Gut Hormone Secretion.

Human Norovirus Cultivation in Nontransformed Stem Cell-Derived Human Intestinal Enteroid Cultures: Success and Challenges.

Rotavirus Calcium Dysregulation Manifests as Dynamic Calcium Signaling in the Cytoplasm and Endoplasmic Reticulum.

Use of Human Intestinal Enteroids to Detect 
Human Norovirus Infectivity.

Two- and Three-Dimensional Bioengineered Human Intestinal Tissue Models for Cryptosporidium.

Sperm Flagellar 1 Binds Actin in Intestinal Epithelial Cells and Contributes to Formation of Filopodia and Lamellipodia.

ICTV Virus Taxonomy Profile: .

Use of organoids to study regenerative responses to intestinal damage.

COPII Vesicle Transport Is Required for Rotavirus NSP4 Interaction with the Autophagy Protein LC3 II and Trafficking to Viroplasms.

Comparison of Microneutralization and Histo-Blood Group Antigen-Blocking Assays for Functional Norovirus Antibody Detection.

Microbial Metabolic Capacity for Intestinal Folate Production and Modulation of Host Folate Receptors.

Gut Bacterial Bouncers: Keeping Viral Pathogens out of the Epithelium.

Bile acids and ceramide overcome the entry restriction for GII.3 human norovirus replication in human intestinal enteroids.

Models of the Small Intestine: Engineering Challenges and Engineering Solutions.

Establishing Human Intestinal Enteroid/Organoid Lines from Preterm Infant and Adult Tissue.

Genetic Manipulation of Human Intestinal Enteroids Demonstrates the Necessity of a Functional Fucosyltransferase 2 Gene for Secretor-Dependent Human Norovirus Infection.

CD300lf is the primary physiologic receptor of murine norovirus but not human norovirus.

Nonculturable agents of viral gastroenteritis.

A Genetically Engineered Rotavirus NSP2 Phosphorylation Mutant Impaired in Viroplasm Formation and Replication Shows an Early Interaction between vNSP2 and Cellular Lipid Droplets.

2.7 Å cryo-EM structure of rotavirus core protein VP3, a unique capping machine with a helicase activity.

Human norovirus exhibits strain-specific sensitivity to host interferon pathways in human intestinal enteroids.

Histo-blood group antigens of glycosphingolipids predict susceptibility of human intestinal enteroids to norovirus infection.

Enteropathogenic Escherichia coli Infection in Cancer and Immunosuppressed Patients.

Telomere dysfunction activates YAP1 to drive tissue inflammation.

Enteroaggregative E. coli Adherence to Human Heparan Sulfate Proteoglycans Drives Segment and Host Specific Responses to Infection.

Plasmid-based reverse genetics for probing phosphorylation-dependent viroplasm formation in rotaviruses.

High-Resolution Mapping of Human Norovirus Antigens via Genomic Phage Display Library Selections and Deep Sequencing.

Epithelial WNT2B and Desert Hedgehog Are Necessary for Human Colonoid Regeneration after Bacterial Cytotoxin Injury.

Rotavirus induces intercellular calcium waves through ADP signaling.

Fusobacteriumnucleatum Adheres to Clostridioides difficile via the RadD Adhesin to Enhance Biofilm Formation in Intestinal Mucus.

Intestinal stem cell-derived enteroids from morbidly obese patients preserve obesity-related phenotypes: Elevated glucose absorption and gluconeogenesis.

Protein-Functionalized Poly(ethylene glycol) Hydrogels as Scaffolds for Monolayer Organoid Culture.

A Millifluidic Perfusion Cassette for Studying the Pathogenesis of Enteric Infections Using Ex-Vivo Organoids.

New Insights and Enhanced Human Norovirus Cultivation in Human Intestinal Enteroids.

Microbial Science Research in the Post-COVID Environment.

Bile Goes Viral.

Organoids to Dissect Gastrointestinal Virus-Host Interactions: What Have We Learned?

Norovirus in Cancer Patients: A Review.

Telomere dysfunction instigates inflammation in inflammatory bowel disease.

Broadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses.

Effect of substrate stiffness on human intestinal enteroids' infectivity by enteroaggregative Escherichia coli.

Use of human tissue stem cell-derived organoid cultures to model enterohepatic circulation.

Drivers of transcriptional variance in human intestinal epithelial organoids.

Organoid Models for Infectious Disease.

Author Correction: Broadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses.

Norovirus Protease Structure and Antivirals Development.

Glycan Recognition in Human Norovirus Infections.

Single-cell sequencing of rotavirus-infected intestinal epithelium reveals cell-type specific epithelial repair and tuft cell infection.

Yersinia pseudotuberculosis YopE prevents uptake by M cells and instigates M cell extrusion in human ileal enteroid-derived monolayers.

Distinct gene expression profiles between human preterm-derived and adult-derived intestinal organoids exposed to : a pilot study.

Rotaviruses: cause of vaccine-preventable disease yet many fundamental questions remain to be explored.

Depletion of the apical endosome in response to viruses and bacterial toxins provides cell-autonomous host defense at mucosal surfaces.

Generation of CRISPR-Cas9-mediated genetic knockout human intestinal tissue-derived enteroid lines by lentivirus transduction and single-cell cloning.

Clinical and In Vitro Evidence Favoring Immunoglobulin Treatment of a Chronic Norovirus Infection in a Patient With Common Variable Immunodeficiency.

Atomic structure of the predominant GII.4 human norovirus capsid reveals novel stability and plasticity.

Rotavirus-Induced Lipid Droplet Biogenesis Is Critical for Virus Replication.

Novel fold of rotavirus glycan-binding domain predicted by AlphaFold2 and determined by X-ray crystallography.

Evaluation of Heat Inactivation of Human Norovirus in Freshwater Clams Using Human Intestinal Enteroids.

Use of Human Intestinal Enteroids to Evaluate Persistence of Infectious Human Norovirus in Seawater.

A DLG1-ARHGAP31-CDC42 axis is essential for the intestinal stem cell response to fluctuating niche Wnt signaling.

CLIC and membrane wound repair pathways enable pandemic norovirus entry and infection.

Human Sapovirus Replication in Human Intestinal Enteroids.

Mapping human norovirus antigens during infection reveals the breadth of the humoral immune response.

Infant and Adult Human Intestinal Enteroids are Morphologically and Functionally Distinct.

A Standardized Antiviral Pipeline for Human Norovirus in Human Intestinal Enteroids Demonstrates No Antiviral Activity of Nitazoxanide.

Hepatobiliary organoids derived from leporids support the replication of hepatotropic lagoviruses.

Nanoparticle-Mediated Therapy with miR-198 Sensitizes Pancreatic Cancer to Gemcitabine Treatment through Downregulation of VCP-Mediated Autophagy.

A Bivalent Human Norovirus Vaccine Induces Homotypic and Heterotypic Neutralizing Antibodies.

Standardization of an antiviral pipeline for human norovirus in human intestinal enteroids demonstrates nitazoxanide has no to weak antiviral activity.

A single nanobody neutralizes multiple epochally evolving human noroviruses by modulating capsid plasticity.

Human intestinal organoids from Cronkhite-Canada syndrome patients reveal link between serotonin and proliferation.

Rotavirus-mediated DGAT1 degradation: A pathophysiological mechanism of viral-induced malabsorptive diarrhea.

N-glycoproteomic analyses of human intestinal enteroids, varying in histo-blood group geno- and phenotypes, reveal a wide repertoire of fucosylated glycoproteins.

2'-Fucosyllactose Inhibits Human Norovirus Replication in Human Intestinal Enteroids.

Divergent responses of human intestinal organoid monolayers using commercial in vitro cytotoxicity assays.

GI.1 Norovirus Neutralizing Antibody Levels Are Correlated with GI.1 Histo-blood Group Antigen-Blocking Antibody Levels.

Bile acid-sensitive human norovirus strains are susceptible to sphingosine-1-phosphate receptor 2 inhibition.