Petra Boukamp

Dual regulation of telomerase activity through c-Myc-dependent inhibition and alternative splicing of hTERT.

Human dermal fibroblasts escape from the long-term phenocopy of senescence induced by psoralen photoactivation.

UV-B-type mutations and chromosomal imbalances indicate common pathways for the development of Merkel and skin squamous cell carcinomas.

The E6 and E7 proteins of the cutaneous human papillomavirus type 38 display transforming properties.

Constitutive overexpression of human telomerase reverse transcriptase but not c-myc blocks terminal differentiation in human HaCaT skin keratinocytes.

The three-dimensional organization of telomeres in the nucleus of mammalian cells.

Authentic fibroblast matrix in dermal equivalents normalises epidermal histogenesis and dermoepidermal junction in organotypic co-culture.

Cell cycle-dependent 3D distribution of telomeres and telomere repeat-binding factor 2 (TRF2) in HaCaT and HaCaT-myc cells.

HaCaT keratinocytes secrete lysosomal cysteine proteinases during migration.

Non-melanoma skin cancer: what drives tumor development and progression?

UV-induced skin cancer: similarities--variations.

Skin aging: a role for telomerase and telomere dynamics?

c-Myc induces chromosomal rearrangements through telomere and chromosome remodeling in the interphase nucleus.

Automatic telomere length measurements in interphase nuclei by IQ-FISH.

Telomere-dependent chromosomal instability.

Confocal reflection imaging of 3D fibrin polymers.

Lack of nidogen-1 and -2 prevents basement membrane assembly in skin-organotypic coculture.

Reversion of tumor phenotype in surface transplants of skin SCC cells by scaffold-induced stroma modulation.

Epidermal homeostasis in long-term scaffold-enforced skin equivalents.

Junctional basement membrane anomalies of skin and mucosa in lipoid proteinosis (hyalinosis cutis et mucosae).

Telomeres rather than telomerase a key target for anti-cancer therapy?

A novel regulator of telomerase. S100A8 mediates differentiation-dependent and calcium-induced inhibition of telomerase activity in the human epidermal keratinocyte line HaCaT.

The multi-step process of human skin carcinogenesis: a role for p53, cyclin D1, hTERT, p16, and TSP-1.

Effects of fibroblasts and microenvironment on epidermal regeneration and tissue function in long-term skin equivalents.

Improved alkaline comet assay protocol for adherent HaCaT keratinocytes to study UVA-induced DNA damage.

Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes.

Impairment of the telomere/telomerase system and genomic instability are associated with keratinocyte immortalization induced by the skin human papillomavirus type 38.

Tumor immune escape by the loss of homeostatic chemokine expression.

A stable niche supports long-term maintenance of human epidermal stem cells in organotypic cultures.

Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1.

Dynamics of telomeres and promyelocytic leukemia nuclear bodies in a telomerase-negative human cell line.

Tissue context-activated telomerase in human epidermis correlates with little age-dependent telomere loss.

Aging and replicative senescence have related effects on human stem and progenitor cells.

Ewing's sarcoma cells with CD57-associated increase of tumorigenicity and with neural crest-like differentiation capacity.

Irradiation with heavy-ion particles changes the cellular distribution of human histone acetyltransferase HAT1.

An inducible Tet-Off-H2B-GFP lentiviral reporter vector for detection and in vivo isolation of label-retaining cells.

3D geometry-based quantification of colocalizations in multichannel 3D microscopy images of human soft tissue tumors.

A decisive function of transforming growth factor-β/Smad signaling in tissue morphogenesis and differentiation of human HaCaT keratinocytes.

Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-):H2O2 ratio and confers anoikis resistance to tumors.

UVA-induced epigenetic regulation of P16(INK4a) in human epidermal keratinocytes and skin tumor derived cells.

Stem cells of the human epidermis and their niche: composition and function in epidermal regeneration and carcinogenesis.

Different domains in nidogen-1 and nidogen-2 drive basement membrane formation in skin organotypic cocultures.

Mechanism of the antiproliferative activity of some naphthalene diimide G-quadruplex ligands.

An organotypic coculture model supporting proliferation and differentiation of medullary thymic epithelial cells and promiscuous gene expression.

WIF1 is expressed by stem cells of the human interfollicular epidermis and acts to suppress keratinocyte proliferation.

The chromatin remodelling complex NoRC safeguards genome stability by heterochromatin formation at telomeres and centromeres.

The hallmarks of fibroblast ageing.

Frailty and telomere length: cross-sectional analysis in 3537 older adults from the ESTHER cohort.

Reproducibility of telomere length assessment: an international collaborative study.

Wnt-3a-activated human fibroblasts promote human keratinocyte proliferation and matrix destruction.

Characterization of Skin Aging-Associated Secreted Proteins (SAASP) Produced by Dermal Fibroblasts Isolated from Intrinsically Aged Human Skin.

Three-Dimensional In Vitro Skin and Skin Cancer Models Based on Human Fibroblast-Derived Matrix.

Subcellular Raman Microspectroscopy Imaging of Nucleic Acids and Tryptophan for Distinction of Normal Human Skin Cells and Tumorigenic Keratinocytes.