A Preclinical Human-Derived Autologous Gastric Cancer Organoid/Immune Cell Co-Culture Model to Predict the Efficacy of Targeted TherapiesJayati Chakrabarti *1, Vivien Koh *2,3, Jimmy Bok Yan So 2,4, Wei Peng Yong 2,3, Yana Zavros 1
1Department of Cellular and Molecular Medicine, University of Arizona, Tucson, 2National University Cancer Institute Singapore, National University Health System, Singapore, 3Cancer Science Institute of Singapore, National University of Singapore, 4Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore
The goals of the protocol are to use this approach to 1) understand the role of the immunosuppressive gastric tumor microenvironment and 2) predict the efficacy of patient response, thus increasing the survival rate of patients.
