This method can help answer key questions in the field of Alzheimer disease research, especially the early events involved in growth cone collapse. The main advantage of this technique is to make it possible to visualize and analyze axonal growth
Inicia sesión o comienza tu prueba gratuita para acceder a este contenido
Here a protocol to investigate the early effects of amyloid-β (Aβ) in the brain is presented. This shows that Aβ induces clathrin-mediated endocytosis and collapse of axonal growth cones. The protocol is useful in studying early effects of Aβ on axonal growth cones and may facilitate prevention of Alzheimer's disease.