Selective Ring-Opening of Non-Activated Aziridines
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Results: Characterization Data for the Products
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Conclusion
Transcribir
The significance of our protocol is rational design of contiguous bisaziridine containing both activated and non-activated aziridines, and subject it to regioselective ring-opening reactions with diverse nucleophiles. The advantage of this techniq
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Contiguous bisaziridines containing non-activated and activated aziridines were synthesized by asymmetric organocatalytic aziridinations and then subjected to chemoselective ring-opening reactions under acidic or basic conditions. The non-activated aziridine ring opens with less reactive nucleophiles under acidic conditions, whereas the activated aziridine ring opens with more reactive nucleophiles under basic conditions.