Hyeonwi Son

Department of Anatomy and Convergence Medical Sciences,
Institute of Health Sciences,
Bio Anti-aging Medical Research Center,
Department of Anatomy and Convergence Medical Sciences, Institute of Health Sciences, Bio Anti-aging Medical Research Center

Gyeongsang National University Medical School

BIOGRAPHY

Hyeonwi Son, Ph.D. is a senior researcher in the Department of Anatomy in the Gyeongsang National University Medical School at the Republic of Korea. He received a Ph.D. in Neurobiology from Gyeongsang National University. As a graduate student, he elucidated mechanisms governing the development of depressive behavior induced by chronic stress. His work identified a causal relationship between depressive behavior and low levels of glutamate-glutamine in the prefrontal cortex. Beginning in 2015, he carried out his postdoctoral fellowship at Gyeongsang National University. As a postdoc, he identified that postnatal astrocyte function supplying glutamine to neurons is important for glutamatergic synapse development in the hippocampus.

PUBLICATIONS

Glutamine has antidepressive effects through increments of glutamate and glutamine levels and glutamatergic activity in the medial prefrontal cortex.

Neuropharmacology 12, 2018 | Pubmed ID: 30266598

Anti-Stress and Anti-Depressive Effects of Spinach Extracts on a Chronic Stress-Induced Depression Mouse Model through Lowering Blood Corticosterone and Increasing Brain Glutamate and Glutamine Levels.

Journal of clinical medicine Oct, 2018 | Pubmed ID: 30384468

Insufficient glutamine synthetase activity during synaptogenesis causes spatial memory impairment in adult mice.

Scientific reports Jan, 2019 | Pubmed ID: 30670758

Calcium Imaging Visualizes Incision-Induced Primary Afferent Sensitization and Its Amelioration by Capsaicin Pretreatment.

The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 2021 | Pubmed ID: 34452938

Pituitary hormones are specifically expressed in trigeminal sensory neurons and contribute to pain responses in the trigeminal system.

Scientific reports Sep, 2021 | Pubmed ID: 34497285

cytoNet: Spatiotemporal network analysis of cell communities.

PLoS computational biology Jun, 2022 | Pubmed ID: 35696439

Meclizine and metabotropic glutamate receptor agonists attenuate severe pain and Ca activity of primary sensory neurons in chemotherapy-induced peripheral neuropathy.

The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 2022 | Pubmed ID: 35772967

INSTITUTIONS

Gyeongsang National University Medical School

University of Texas Health Science Center at San Antonio

JOVE ARTICLES

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice

Hyeonwi Son¹,

Ju Hwan Yang²,

Hyun Joon Kim^*,1,

Dong Kun Lee^*,3

¹Department of Anatomy and Convergence Medical Sciences, Institute of Health Sciences, Bio Anti-aging Medical Research Center, Gyeongsang National University Medical School,

²Department of Biological Sciences, Pusan National University,

³Department of Physiology and Convergence Medical Sciences, Institute of Health Sciences, Gyeongsang National University Medical School

Behavior

In Vivo Calcium Imaging of Neuronal Ensembles in Networks of Primary Sensory Neurons in Intact Dorsal Root Ganglia

John Shannonhouse¹,

Ruben Gomez¹,

Hyeonwi Son¹,

Yan Zhang¹,

Yu Shin Kim^1,2

¹Department of Oral & Maxillofacial Surgery, School of Dentistry, University of Texas Health Science Center at San Antonio,

²Programs in Integrated Biomedical Sciences, Translational Sciences, Biomedical Engineering, Radiological Sciences, University of Texas Health Science Center at San Antonio

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