Juan Iovanna

Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis.

PAP/HIP protein is an obesogenic factor.

Genetic inactivation of Nupr1 acts as a dominant suppressor event in a two-hit model of pancreatic carcinogenesis.

Pancreatitis-associated protein does not predict disease relapse in inflammatory bowel disease patients.

Oligomerization and phosphorylation dependent regulation of ArgBP2 adaptive capabilities and associated functions.

Development of an ELISA detecting Tumor Protein 53-Induced Nuclear Protein 1 in serum of prostate cancer patients.

Pancreatic cancer-induced cachexia is Jak2-dependent in mice.

Further characterization of HDAC and SIRT gene expression patterns in pancreatic cancer and their relation to disease outcome.

P8 deficiency increases cellular ROS and induces HO-1.

A subgroup of pancreatic adenocarcinoma is sensitive to the 5-aza-dC DNA methyltransferase inhibitor.

The thymus-specific serine protease TSSP/PRSS16 is crucial for the antitumoral role of CD4(+) T cells.

Methodological aspects of the molecular and histological study of prostate cancer: focus on PTEN.

Transcriptomic analysis predicts survival and sensitivity to anticancer drugs of patients with a pancreatic adenocarcinoma.

Deciphering the cellular source of tumor relapse identifies CD44 as a major therapeutic target in pancreatic adenocarcinoma.

Defects in mitophagy promote redox-driven metabolic syndrome in the absence of TP53INP1.

Functional Characterization of Nupr1L, A Novel p53-Regulated Isoform of the High-Mobility Group (HMG)-Related Protumoral Protein Nupr1.

The Aurora A-HP1γ pathway regulates gene expression and mitosis in cells from the sperm lineage.

IER3 in pancreatic carcinogenesis.

Targeting CD44 as a novel therapeutic approach for treating pancreatic cancer recurrence.

Response to "Is the Reg3α (HIP/PAP) Protein Really an Obesogenic Factor?".

IL17 Functions through the Novel REG3β-JAK2-STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer.

A Mycobacterium tuberculosis Dormancy Antigen Differentiates Latently Infected Bacillus Calmette-Guérin-vaccinated Individuals.

α-Lipoic Acid Protects Against Ischemia-Reperfusion Injury in Simultaneous Kidney-Pancreas Transplantation.

Pivotal Role of the Chromatin Protein Nupr1 in Kras-Induced Senescence and Transformation.

REG3β Plays a Key Role in IL17RA Protumoral Effect-Response.

Determinants of the pKa values of ionizable residues in an intrinsically disordered protein.

Pancreatitis promotes oncogenic Kras(G12D)-induced pancreatic transformation through activation of Nupr1.

Redox-sensitive TP53INP1 SUMOylation as an oxidative stress sensor to activate TP53.

GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer.

The promise of epigenomic therapeutics in pancreatic cancer.

A pancreatic ductal adenocarcinoma subpopulation is sensitive to FK866, an inhibitor of NAMPT.

Stratification and therapeutic potential of PML in metastatic breast cancer.

Autophagy Induced during Pancreatitis Promotes -Dependent Transformation in the Pancreas.

Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma.

Gene expression profiling of patient-derived pancreatic cancer xenografts predicts sensitivity to the BET bromodomain inhibitor JQ1: implications for individualized medicine efforts.

[Autophagy contributes to the initiation of pancreatic cancer].

Combined AURKA and H3K9 Methyltransferase Targeting Inhibits Cell Growth By Inducing Mitotic Catastrophe.

REG3β modifies cell tumor function by impairing extracellular vesicle uptake.

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions.

Speeding towards individualized treatment for pancreatic cancer by taking an alternative road.

Factors released by the tumor far microenvironment are decisive for pancreatic adenocarcinoma development and progression.

Prevalence of Microsatellite Instability in Intraductal Papillary Mucinous Neoplasms of the Pancreas.

Cadherin-1 and cadherin-3 cooperation determines the aggressiveness of pancreatic ductal adenocarcinoma.

Pancreatic Adenocarcinoma Therapeutic Targets Revealed by Tumor-Stroma Cross-Talk Analyses in Patient-Derived Xenografts.

BTN3A is a prognosis marker and a promising target for Vγ9Vδ2 T cells based-immunotherapy in pancreatic ductal adenocarcinoma (PDAC).

Amphipathic helical peptides hamper protein-protein interactions of the intrinsically disordered chromatin nuclear protein 1 (NUPR1).

Optimization of a Bioluminescence Resonance Energy Transfer-Based Assay for Screening of Trypanosoma cruzi Protein/Protein Interaction Inhibitors.

Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes.

E2F signature is predictive for the pancreatic adenocarcinoma clinical outcome and sensitivity to E2F inhibitors, but not for the response to cytotoxic-based treatments.

Pancreatic Ductal Adenocarcinoma: A Strong Imbalance of Good and Bad Immunological Cops in the Tumor Microenvironment.

[Multi-omic approaches reveal new therapeutic targets for the treatment of pancreatic cancer].

The chromatin nuclear protein NUPR1L is intrinsically disordered and binds to the same proteins as its paralogue.

α-lipoic acid reduces postreperfusion syndrome in human liver transplantation - a pilot study.

Epigenetics of gastrointestinal diseases: notes from a workshop.

Chloroquine plays a cell-dependent role in the response to treatment of pancreatic adenocarcinoma.

Mechanisms Underlying the Regulation of HP1γ by the NGF-PKA Signaling Pathway.

Self-assembling supramolecular dendrimer nanosystem for PET imaging of tumors.

Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis.

Ribonuclease MCPiP1 contributes to the loss of micro-RNA-200 family members in pancreatic cancer cells.

Pancreatic cancer chemo-resistance is driven by tumor phenotype rather than tumor genotype.

Prognostic significance of circulating PD-1, PD-L1, pan-BTN3As, BTN3A1 and BTLA in patients with pancreatic adenocarcinoma.

Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis.

Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF.

Pancreatic Cancer Heterogeneity Can Be Explained Beyond the Genome.

Aurora kinase B-phosphorylated HP1α functions in chromosomal instability.

Dendrimers as Competitors of Protein-Protein Interactions of the Intrinsically Disordered Nuclear Chromatin Protein NUPR1.

Can the plasma PD-1 levels predict the presence and efficiency of tumor-infiltrating lymphocytes in patients with metastatic melanoma?

Pancreatic Cancer Organoids for Determining Sensitivity to Bromodomain and Extra-Terminal Inhibitors (BETi).

Flavonoid-alkylphospholipid conjugates elicit dual inhibition of cancer cell growth and lipid accumulation.

Dynamics of the intrinsically disordered protein NUPR1 in isolation and in its fuzzy complexes with DNA and prothymosin α.

Emerging epigenomic landscapes of pancreatic cancer in the era of precision medicine.

Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm.

PML hyposumoylation is responsible for the resistance of pancreatic cancer.