We appreciate the financial support from the National TCM Clinical Excellent Talents Training Program (National TCM Renjiao Letter [2022] No. 1), 100 Talent Plan Project of Hospital of Chengdu University of Traditional Chinese Medicine (Hospital office [2021] 42), Special subject of scientific research of Sichuan Administration of Traditional Chinese Medicine (2021MS093, 2021MS539, 2023MS608), 2022 Tianfu Qingcheng Plan Tianfu Science and Technology Leading Talents Project (Chuan Qingcheng No. 1090) and Sichuan science and technology program of Science &#38; Technology Department of Sichuan Province (2022YF0392).

The protocol is carried out in accordance with the Declaration of Helsinki. It is approved by the Approval Committee of the Department of Respiratory Medicine, Hospital of Chengdu University of Traditional Chinese Medicine. The number is KY2022009. Informed consent was obtained.
1. Patient candidacy screening
<ol>
	<li>Inclusion criteria
	<ol>
		<li>Ensure age is between 50-65 years. Ensure that the patients meet the diagnosis of stable COPD and lung and kidney qi deficiency. Ensure patients volunteer to participate in and comply with study requirements and sign informed consent forms.</li>
		<li>For the diagnosis of stable COPD, reference the Global Strategy for The Diagnosis Management and Prevention of Chronic Obstructive Pulmonary Disease 2022 Report15. Ensure that patients have a modified Medical Research Council grade (mMRC) &#8804; 2; the degree of airflow limitation is mild or moderate, which means the forced expiratory volume in 1 s (FEV1) &#8805; 50% of the predicted value.</li>
		<li>Ensure that the diagnosis of COPD with wheezing due to lung and kidney qi deficiency refers to the corresponding criteria in the Guidelines for the Management of Chronic Obstructive Pulmonary Disease in Chinese Medicine16. Main symptoms include 1) wheezing, shortness of breath, aggravated by exercise; 2) weakness, or spontaneous sweating, aggravated by exercise; 3) Susceptibility to cold and wind; 4) Senselessness and weakness of the waist and knees; 5) Tinnitus, dizziness, or floaters; 6) Frequent urination, nocturnal urination, or coughing and drowning; 7) Pale tongue with white coating and sunken or weak pulse. If two of 1), 2), and 3) and two of 4), 5), 6), and 7) are present, diagnose it as COPD.</li>
	</ol>
	</li>
	<li>Exclusion criteria
	<ol>
		<li>Exclude patients with diseases that seriously affect breathing or quality of life, such as acute myocardial infarction, stroke, Alzheimer&#39;s disease, and mental illness.</li>
		<li>Exclude patients with severe cognitive and motor dysfunction and uncooperative.</li>
	</ol>
	</li>
</ol>
2. Material preparation
<ol>
	<li>Check equipment to be used for disinfection: cotton balls with 75% ethanol, sterile forceps, and medical blades.</li>
	<li>Prepare medicinal seeds in advance. Sieve the seeds of Vaccaria segetalis with spherical shape to obtain uniform seeds 2 mm in diameter, as shown in Figure 1A.</li>
	<li>Prepare the medical tape and auricular acupressure patch template. Use hypoallergenic ultra-thin paper tape with a width of 5 cm, as shown in Figure 1B. Prepare a 5 cm x 8.5 cm white auricular acupressure patch template, as shown in Figure 1B. 
	NOTE: For people who are allergic to regular tape, use desensitizing tape. Be careful not to get the tape wet, or the skin may become infected.</li>
</ol>
3. Treatment preparation
<ol>
	<li>Ensure cleanliness and hygiene in the environment to avoid pollution.</li>
	<li>Ask the operator to wash hands with a disinfectant. Then, wipe fingers with cotton balls containing 75% ethanol.</li>
	<li>Place the seeds of Vaccaria segetalis on the auricular acupressure patch template. Stick them down with medical tape, as shown in Figure 1C. Maintain strict disinfection to avoid infection.</li>
</ol>
3. Treatment steps
<ol>
	<li>Body position: Ask the patient to be seated.</li>
	<li>Disinfection and positioning: Ask the operator to fix the patient&#39;s auricle. Keep the patient in the sitting position. Use one hand to immobilize the patient&#39;s head. Use 75% ethanol cotton balls for one-time skin disinfection.</li>
	<li>Locating the points: Follow the points in the national standard Nomenclature and location of auricular points issued by the National Committee for Standardization in 200817. Based on the locations shown in Figure 1D and Table 1, find the positions of the ear points of Lung (CO14), Spleen (CO13), Kidney (CO10), Shen Men (TF4), and Ping Chuan (AT1.2.4i).</li>
	<li>Patching: Remove the prepared auricular acupressure patch and stick it on the corresponding ear point. For each ear point, use a single ear patch.</li>
	<li>Compression: After applying the patch, apply compression using direct pressure. Place the thumb and index finger on both sides of the ear auricle. Apply relative pressure to the medical seed patch on the ear point, ensuring that the patient feels mild pain but does not interfere with sleep. 
	NOTE: Pressure intensity is determined according to different pain levels on the Visual Analog Scoring Tool (VAS)18: moderate pain on a scale of 1 to 3 is chosen as the criterion for pressure intensity.</li>
</ol>
5. Treatment course
<ol>
	<li>Press the auricular pressure points 3x a day. Apply pressure once at 9:00 am, 3:00 pm, and 9:00 pm. Keep the intensity of the pressure between 1-3 on the VAS pain scale. Alternate compressions every 3 days, alternating on both ears, for 12 days.</li>
	<li>Check the patch daily and replace it if it is wet or the ear cavity has skin lesions, frostbite, or inflammation. If none of them occur, keep the patch. The patches exert buried pressure or moderate pressure; ask the patient not to rub the patch to prevent contamination of the skin caused by infection. Ensure that the ear patches are applied to the auricular points and do not affect the patient&#39;s sleep.</li>
</ol>
6. Efficacy evaluation
NOTE: Efficacy is judged by objective and subjective indicators together. When it comes to subjective indicators such as scale filling, patients must complete the scoring independently without any suggestive reminder.
<ol>
	<li>Instruct patient to perform tests for pulmonary function indices, including FEV1, FVC (forced vital capacity), and FEV1/FVC. The increase in the above indicators after receiving treatment suggests that the therapy is effective.</li>
	<li>Use the TCM symptom rating scale to evaluate efficacy19. Changes of more than 2 points before and after treatment indicate that the treatment has clinical significance.</li>
	<li>Use mMRC Grade to evaluate patient&#39;s quality of life. Patients with a score of 0-1 mean light dyspnea; between 2-4 mean heavy dyspnea. Changes of more than 1 point in patient&#39;s mMRC scores before and after treatment indicate that the treatment has clinical significance.</li>
</ol>

Traditional Chinese Medicine Ear Point Therapy for Wheezing in COPD Patients

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The authors have nothing to disclose.

Modern medicine treats COPD patients mainly with long-acting &#946;2 agonists (LABAs), long-acting muscarinic antagonists (LAMAs), and ICS23. Chinese medicine classifies COPD as wheezing based on the clinical characteristics of cough, sputum, shortness of breath, and dyspnea24. At the same time, Chinese medicine believes that the 12 meridians are connected to the ear. Auricular points are interconnected with meridians, tissues, and organs. It is closely related to the body&...

Chronic obstructive pulmonary disease (COPD) is a common, preventable, and treatable chronic respiratory disease. The disease is characterized by persistent respiratory symptoms and airflow limitation, usually associated with airway and/or alveolar abnormalities caused by significant exposure to harmful particles or gases1. In 2016, more than 3 million people died from COPD, accounting for 6% of all deaths worldwide2. Healthcare costs for COPD are an increasing burden on the world3. COPD is now a major public health problem with high rates of death, morbidity, disability, and disease burden4.
The main symptoms of COPD are chronic cough, sputum, dyspnea, wheezing, and chest tightness. Depending on the symptoms and lung function, it can be divided into an acute exacerbation phase and a stable phase5. Aggressive treatment during the stable phase can effectively reduce the number of acute exacerbations and delay the deterioration of lung function. Currently, treatment in the stable phase relies largely on pharmacological treatments such as bronchodilators, glucocorticoids, and expectorants. Non-pharmacological treatment modalities still have limitations6. The experiment here provides a special traditional Chinese medicine therapy, auricular acupressure, to expand the treatment modality.
For in-ear acupressure, small round granular objects are applied to the surface of the ear points. Moderate kneading, pressing, pinching, and squeezing are used to produce stimulation sensations such as soreness, numbness, swelling, and pain. As the main ingredient in auricular pressure, the seeds of Vaccaria segetalis can stimulate acupuncture points for the treatment of disease7. It is a non-drug external treatment method for the treatment of diseases8. The therapy is easy to use, inexpensive, safe, has no side effects, and is less prone to infection. It has certain advantages, like improving clinical symptoms, quality of life, and reducing acute exacerbations. It is suitable for adjuvant treatment of patients with stable COPD9.
As for the mechanism of auricular acupressure for wheezing, Chinese medicine believes that pressing certain acupuncture points on the auricle can communicate with qi, blood, meridians, and internal and external organs and harmonize the internal and external organs. In this way, acupuncture can play a role in regulating qi and relieving wheezing10. Modern medicine has shown that auricular acupressure stimulates blood vessels, nerves, and lymphatic vessels in the ear11. It regulates the immune system and suppresses the inflammatory response by activating the cholinergic anti-inflammatory signaling pathway, which in turn relieves bronchial inflammation and alleviates wheezing symptoms. The theory of holographic biology states that the auricle is allometric to the body&#39;s information. According to the correspondence, there could be a connection between auricular acupressure and wheezing symptoms12.
According to related studies, lung and kidney qi deficiency account for 23.20% of COPD in the stable stage13. The patients have frequent chronic coughs with wheezing, which means deficiency in the lungs; simultaneously, cold intolerance, weakness in the waist and knees, and self-perspiration show a deficiency in the kidney14. In this experiment, we implemented auricular acupressure for COPD patients with lung and kidney qi deficiency. In identifying wheezes of the lung and kidney qi deficiency, reference was made to the 2020 edition of the Committee on Auricular Acupuncture Diagnosis and Treatment of the Chinese Society of Acupuncture and Moxibustion8. The ear points formulated for this experiment were Lung (CO14), Spleen (CO13), Kidney (CO10), Shen Men (TF4), and Ping Chuan (AT1.2.4i).
The aim of this study is to provide a non-pharmacological treatment modality for stable COPD patients with wheezing and lung and kidney qi deficiency using auricular acupressure. Auricular acupressure was introduced after screening patients for a stable phase of COPD. The treatment protocol is clinically simple, safe, and cost-effective.
CASE PRESENTATION: 
The patient is a 64-year-old male from Sichuan, China. He has been experiencing repeated cough and sputum for the past 5 years, along with worsening chest tightness over the last month. The patient has had diabetes for 5 years and has been taking metformin to manage his blood sugar levels, although he does not regularly monitor them. Additionally, he has a history of hypertension for 7 years and takes amlodipine besylate orally to control his blood pressure, which is also not regularly monitored. The patient denies any surgical history, trauma history, or blood transfusions. He smoked an average of 2 packs per day for 30 years but quit smoking 10 years ago. Furthermore, the patient denies any family genetic history.
Diagnosis, Assessment, and Plan: 
After the doctor&#39;s specialized examination of the patient, he found a barrel chest and widened rib space. Chest CT showed chronic bronchitis, emphysema, and coronary artery calcification. Pulmonary function showed that the patient had moderate obstructive ventilation dysfunction, slightly obstructed airflow in the large airways, and increased total airway resistance. Combined with the patient&#39;s symptoms and signs, auxiliary examinations, and past medical history, a diagnosis of chronic obstructive pulmonary disease, hypertension, and diabetes mellitus was made. For treatment, Budesonide, Glycopyrronium Bromide, and Formoterol Fumarate Inhalation were performed twice daily in the morning and in the evening15. Additionally, hydroxypropyl theophylline intravenous drip (2 mL: 0.25 g, dilute 1 vial with 5% of 250 mL sugar water) was administered 1x day16. Auricular acupressure was given to relieve wheezing.

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auricular acupressure as an adjuvant treatment for wheezing in stable chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a major public health problem. Due to the restriction of expiratory airflow, it is characterized by emphysematous destruction of the lungs. Shortness of breath is one of the main clinical symptoms. Auricular acupressure is a clinical therapy characteristic of Chinese medicine that treats the disease by compressing ear points. Usually, the seeds of Vaccaria segetalis are used to stimulate ear points, which has the effect of regulating qi and alleviating wheezing. In this paper, we propose this characteristic therapy of traditional Chinese medicine (TCM) for the clinical symptoms of wheezing of lung and kidney qi deficiency type in stable COPD patients. Ear points are selected as the treatment protocol for Lung (CO14), Spleen (CO13), Kidney (CO10), Shen Men (TF4), and Ping Chuan (AT1.2.4i) points. The protocol describes a case study using auricular acupressure for a patient with chronic obstructive pulmonary disease to relieve wheezing symptoms.

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Auricular Acupressure as an Adjuvant Treatment for Wheezing in Stable Chronic Obstructive Pulmonary Disease

The above protocol describes a controlled trial to investigate the efficacy of auricular acupressure in improving wheezing symptoms in stable COPD patients. For this study, 1 patient who met the criteria was enrolled and completed the trial. The patient was male and 64 years old. The patient suffered from chronic obstructive pulmonary disease for 5+ years. Long-term regular treatment with inhalation preparations was administered for long-term cough and wheezing.
The patient was admitted to the...

Read this Scientific Article Protocol about Auricular Acupressure as an Adjuvant Treatment for Wheezing in Stable Chronic Obstructive Pulmonary Disease at JoVE.com

This protocol describes an effective therapy using auricular acupressure to relieve wheezing symptoms in stable chronic obstructive pulmonary disease.

Chronic obstructive pulmonary disease (COPD) is a major public health problem. Due to the restriction of expiratory airflow, it is characterized by ...

auricular-acupressure-as-an-adjuvant-treatment-for-wheezing-stable

Research

JoVE Journal

Medicine

Auricular Acupressure Procedure for a Patient with Chronic Obstructive Pulmonary Disease

623 Views.  University of Traditional Chinese Medicine.  This protocol describes an effective therapy using auricular acupressure to relieve wheezing symptoms in stable chronic obstructive pulmonary disease.

Traditional Chinese Medicine Ear Point Therapy for Wheezing in COPD Patients

Summary