Mast Cells in the Microenvironment of Hepatocellular Carcinoma Confer Favorable Prognosis: A Retrospective Study using QuPath Image Analysis SoftwareEsraa Ali 1, Lenka Červenková 2,3, Richard Pálek 2,4, Filip Ambrozkiewicz 1, Sergii Pavlov 1, Wenjing Ye 1, Petr Hošek 2, Ondrej Daum 5,6, Václav Liška 2,4, Kari Hemminki 1,7, Andriy Trailin 1
1Laboratory of Translational Cancer Genomics, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, 2Laboratory of Cancer Treatment and Tissue Regeneration, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, 3Department of Pathology, Third Faculty of Medicine, Charles University, 4Department of Surgery and Biomedical Center, Faculty of Medicine in Pilsen, Charles University, 5Sikl's Institute of Pathology, Faculty of Medicine and Teaching Hospital in Pilsen, Charles University, 6Bioptická Laboratoř s.r.o., 7Department of Cancer Epidemiology, German Cancer Research Center
The presence of mast cells in the inner margin and peritumor areas of hepatocellular carcinoma after resection confers a favorable prognosis. This study endorses QuPath image analysis software as a promising platform that could meet the need for reproducibility, consistency, and accuracy in digital pathology.
