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JoVE Journal

Bioengineering

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Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering

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08:04 min

April 25th, 2013

April 25th, 2013

14,195 Views

0:05

Title

1:22

Biaxial Loading Bioreactor Design

3:35

Immobilization of Samples With Agarose

4:38

Mechanical Loading of Tissue Constructs

6:25

Results: Mechanical Loading Alters Extracellular Matrix Depositing in Tissue Engineered Cartilage

7:44

Conclusion

We designed a novel mechanical loading bioreactor that can apply uniaxial or biaxial mechanical strain to a cartilage biocomposite prior to transplantation into an articular cartilage defect.

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