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University of Texas San Antonio

1 ARTICLES PUBLISHED IN JoVE

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Immunology and Infection

Intratracheal Inoculation of Fischer 344 Rats with Francisella tularensis
Jesse Q. Nguyen 1, Xhavit Zogaj 1, Aanuoluwa A. Adelani 1, Ping Chu 2, Jieh-Juen Yu 1, Bernard P. Arulanandam 1, Karl E. Klose 1
1South Texas Center for Emerging Infectious Diseases, University of Texas San Antonio, 2Midwestern University

This protocol describes intratracheal inoculations of Fischer 344 rats with Francisella tularensis. This procedure mimics pulmonary exposure of humans to this potential biothreat agent and can be used to test vaccine and therapeutic efficacy against pulmonary tularemia.

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