Fission Yeast as a Platform for Antibacterial Drug Screens Targeting Bacterial Cytoskeleton ProteinsSakshi Mahesh Poddar 1,2, Srijita Roy 1,2, Ajay Kumar Sharma 1,2, Ramanujam Srinivasan 1,2
1School of Biological Sciences, National Institute of Science Education and Research, 2Homi Bhabha National Institutes
Fission yeast is used here as a heterologous host to express bacterial cytoskeletal proteins such as FtsZ and MreB as translational fusion proteins with GFP to visualize their polymerization. Also, compounds that affect polymerization are identified by imaging using a fluorescence microscope.
