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New York State Psychiatric Institute

3 ARTICLES PUBLISHED IN JoVE

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Immunology and Infection

Assessing Cellular Stress and Inflammation in Discrete Oxytocin-secreting Brain Nuclei in the Neonatal Rat Before and After First Colostrum Feeding
Benjamin Y. Klein 1, Hadassah Tamir 1,2,3, Muhammad Anwar 1, Robert J. Ludwig 1, Jasmine H. Kaidbey 1, Sara B. Glickstein 4, Martha G. Welch 1,2
1Department of Psychiatry, Columbia University, 2Department of Pathology & Cell Biology, Columbia University Medical Center, 3Department of Psychiatry, Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, 4EB Sciences

Here, we present a protocol to isolate brain nuclei in the neonatal rat brain in conjunction with first colostrum feeding. This technique allows the study of nutrient insufficiency stress in the brain as modulated by enterocyte signaling.

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Neuroscience

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
Garrett Salzman 1, Jocelyn Kim 1, Guillermo Horga *1,2, Kenneth Wengler *1,2
1New York State Psychiatric Institute, 2Department of Psychiatry, Columbia University

This protocol shows how to acquire neuromelanin-sensitive magnetic resonance imaging data of the substantia nigra.

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Neuroscience

An Open-Source Virtual Reality System for the Measurement of Spatial Learning in Head-Restrained Mice
Clay Lacefield 1,2, Hongtao Cai 1, Huong Ho 1, Carla Dias 1, Hannah Chung 1, René Hen 1,2, Gergely F. Turi 1,2
1Division of Systems Neuroscience, New York State Psychiatric Institute, 2Department of Psychiatry, Columbia University

Here, we present a simplified open-source hardware and software setup for investigating mouse spatial learning using virtual reality (VR). This system displays a virtual linear track to a head-restrained mouse running on a wheel by utilizing a network of microcontrollers and a single-board computer running an easy-to-use Python graphical software package.

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