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Nemours/Alfred I. duPont Hospital for Children

1 ARTICLES PUBLISHED IN JoVE

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Chemistry

Radiosynthesis of 1-(2-[18F]Fluoroethyl)-L-Tryptophan using a One-pot, Two-step Protocol
Xuyi Yue 1,2, Rahul M. Nikam 1,2, Heidi H. Kecskemethy 1,2, Vinay V. R. Kandula 2, Stephen J. Falchek 3, Lauren W. Averill 1,2, Sigrid A. Langhans 1,4
1Diagnostic & Research PET/MRI Center, Nemours/Alfred I. duPont Hospital for Children, 2Department of Radiology, Nemours/Alfred I. duPont Hospital for Children, 3Department of Neurology, Nemours/Alfred I. duPont Hospital for Children, 4Department of Biomedical Research, Nemours/Alfred I. duPont Hospital for Children

Here, we describe the radiosynthesis of 1-(2-[18F]Fluoroethyl)-L-tryptophan, a positron emission tomography imaging agent for studying tryptophan metabolism, using a one-pot, two-step strategy in a radiochemistry synthesis system with good radiochemical yields, high enantiomeric excess, and high reliability.

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