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University of Windsor

3 ARTICLES PUBLISHED IN JoVE

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Medicine

Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen
Dennis Ma 1, Jonathan Collins 2, Tomas Hudlicky 2, Siyaram Pandey 1
1Department of Chemistry and Biochemistry, University of Windsor, 2Chemistry Department and Centre for Biotechnology, Brock University

We have synthesized a novel analogue of pancratistatin with comparable anti-cancer activity as native pancratistatin; interestingly, combinatory treatment with tamoxifen yielded a drastic enhancement in apoptotic and autophagic induction by mitochondrial targeting with minimal effect on noncancerous fibroblasts. Thus, JCTH-4 in combination with tamoxifen could provide a safe anti-cancer therapy.

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Chemistry

Preparation and Reactivity of a Triphosphenium Bromide Salt: A Convenient and Stable Source of Phosphorus(I)
Stephanie C. Kosnik 1, Justin F. Binder 1, Maxemilian C. Nascimento 1, Charles L. B. Macdonald 1
1Department of Chemistry and Biochemistry, University of Windsor

The synthesis of a triphosphenium bromide salt is described and its use as a P+ transfer agent is outlined by reactions with an N-heterocyclic carbene and an anionic bisphosphine, yielding an NHC-stabilized P(I) cation and a P(I) containing zwitterion, respectively.

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Engineering

Measuring the Time-Evolution of Nanoscale Materials with Stopped-Flow and Small-Angle Neutron Scattering
Elizabeth G. Kelley 1, Michael H. L. Nguyen 2, Drew Marquardt 2,3, Brian B. Maranville 1, Ryan P. Murphy 1
1NIST Center for Neutron Research, National Institute of Standards and Technology, 2Department of Chemistry and Biochemistry, University of Windsor, 3Department of Physics, University of Windsor

This protocol presents the use of a stopped-flow sample environment to quickly mix multiple liquid solutions in situ during a small-angle neutron scattering measurement and to study kinetic processes on nanometer length scales and second time scales.

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