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University of California Irvine

2 ARTICLES PUBLISHED IN JoVE

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Medicine

Stem Cell Transplantation Strategies for the Restoration of Cognitive Dysfunction Caused by Cranial Radiotherapy
Munjal M. Acharya *1, Dante E. Roa *1, Omar Bosch 1, Mary L. Lan *1, Charles L. Limoli 1
1Department of Radiation Oncology, University of California Irvine

Brain tumor patients routinely undergo cranial radiotherapy, and while beneficial, this treatment often results in debilitating cognitive dysfunction. This serious unresolved problem has at present, no clinical recourse, and has driven our efforts to devise stem cell based therapies for the recovery of radiation-induced cognitive decrements.

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Medicine

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy
Lori- Ann Christie 1, Munjal M. Acharya 1, Charles L. Limoli 1
1Department of Radiation Oncology, University of California Irvine

Cognitive impairment resulting from the radiotherapeutic management of brain tumors represents a clinically intractable condition that adversely impacts quality of life. The capability to critically evaluate potential interventions for ameliorating radiation-induced cognitive decrements ultimately depends on the capability to undertake rigorous quantitative assessments of cognition.

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