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Institute for Chemical and Bioengineering, ETH Zurich

3 ARTICLES PUBLISHED IN JoVE

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Bioengineering

Fluorescence detection methods for microfluidic droplet platforms
Xavier Casadevall i Solvas 1, Xize Niu 1, Katherine Leeper 1, Soongwon Cho 1, Soo-Ik Chang 2, Joshua B. Edel 1, Andrew J. deMello 3
1Department of Chemistry, Imperial College London , 2Department of Biochemistry, Protein Chip Research Center, Chungbuk National University, 3Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zurich

Droplet-based microfluidic platforms are promising candidates for high throughput experimentation since they are able to generate picoliter, self-compartmentalized vessels inexpensively at kHz rates. Through integration with fast, sensitive and high resolution fluorescence spectroscopic methods, the large amounts of information generated within these systems can be efficiently extracted, harnessed and utilized.

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Chemistry

Microfluidic Pneumatic Cages: A Novel Approach for In-chip Crystal Trapping, Manipulation and Controlled Chemical Treatment
Afshin Abrishamkar 1,2, Markos Paradinas 3, Elena Bailo 4, Romen Rodriguez-Trujillo 5, Raphael Pfattner 5, René M. Rossi 1, Carmen Ocal 5, Andrew J. deMello 2, David B. Amabilino 6, Josep Puigmartí-Luis 1
1Empa - Swiss Federal Laboratories for Materials Science and Technology, 2Institute of Chemical and Bioengineering, Department of Chemistry and Applied Bioscience, ETH Zurich, 3ICN2-Institut Catala de Nanociencia i Nanotecnologia, 4WITec GmbH, 5Institut de Ciència de Materials de Barcelona, 6School of Chemistry, The University of Nottingham

Herein, we describe the fabrication and operation of a double-layer microfluidic system made of polydimethylsiloxane (PDMS). We demonstrate the potential of this device for trapping, directing the coordination pathway of a crystalline molecular material and controlling chemical reactions onto on-chip trapped structures.

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Chemistry

Microfluidic-based Synthesis of Covalent Organic Frameworks (COFs): A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface
Afshin Abrishamkar 1, David Rodríguez-San-Miguel 2, Jorge Andrés Rodríguez Navarro 3, Romen Rodriguez-Trujillo 4, David B. Amabilino 5, Ruben Mas-Ballesté 2, Félix Zamora 2,6,7, Andrew J. deMello 1, Josep Puigmarti-Luis 1
1Institute of Chemical and Bioengineering, Department of Chemistry and Applied Bioscience, ETH Zurich, 2Departamento de Química Inorgánica, Universidad Autónoma de Madrid, 3Departamento de Química Inorgánica, Universidad de Granada, 4Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), 5School of Chemistry, University of Nottingham, 6Condensed Matter Physics Center (IFMAC), Universidad Autónoma de Madrid, 7Instituto Madrileño de Estudios Avanzados en Nanociencia (IMDEA Nanociencia)

We present a novel microfluidic-based method for synthesis of covalent organic frameworks (COFs). We demonstrate how this approach can be used to produce continuous COF fibers, and also 2D or 3D COF structures on surfaces.

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