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Smith and Nephew

1 ARTICLES PUBLISHED IN JoVE

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Bioengineering

Induction of Adhesion-dependent Signals Using Low-intensity Ultrasound
James Roper 1, Andrew Harrison 2, Mark D. Bass 1
1School of Biochemistry, University of Bristol, 2Smith and Nephew

This protocol describes the stimulation of cultured fibroblasts with low-intensity pulsed ultrasound, which drives focal adhesion formation and Rac1 activation by mimicking engagement of the transmembrane matrix receptor, syndecan-4. This approach allows investigation of a successful clinical technique at the cellular level, thereby providing opportunities for refinement of the therapy.

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