Examining the Role of Nasopharyngeal-associated Lymphoreticular Tissue (NALT) in Mouse Responses to VaccinesEmily D. Cisney 1, Stefan Fernandez 1, Shannan I. Hall 1, Gale A. Krietz 1, Robert G. Ulrich 1
1U.S. Army Medical Research Institute of Infectious Diseases
Methods to examine contributions of the nasopharyngeal-associated lymphoreticular tissues (NALT) to nasal and systemic immune responses of mice to intranasal vaccines are described. We demonstrate a surgical procedure to establish a NALT-dependent mouse model and ex vivo cultures of extracted NALT.