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Royal Infirmary of Edinburgh

3 ARTICLES PUBLISHED IN JoVE

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Medicine

In situ Transverse Rectus Abdominis Myocutaneous Flap: A Rat Model of Myocutaneous Ischemia Reperfusion Injury
Marie-Claire Edmunds 1, Stephen Wigmore 1, David Kluth 2
1Department of Surgery, Royal Infirmary of Edinburgh, 2Department of Nephrology, Royal Infirmary of Edinburgh

Free tissue transfer is widely employed in reconstructive surgery to restore form and function following oncological resection and trauma. Preconditioning this tissue prior to surgery may improve outcome. This article describes an in situ transverse rectus abdominis myocutaneous flap (TRAM) in rats as a means for testing preconditioning strategies.

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Medicine

Renal Ischaemia Reperfusion Injury: A Mouse Model of Injury and Regeneration
Emily E. Hesketh 1, Alicja Czopek 1, Michael Clay 1, Gary Borthwick 1, David Ferenbach 1, David Kluth 1, Jeremy Hughes 1
1MRC Centre for Inflammation Research, University of Edinburgh

The mouse model of renal ischaemia reperfusion injury described here comprises of a right nephrectomy that provides control tissue and clamping of the left renal pedicle to induce ischaemia that results in acute kidney injury. This model uses a midline laparotomy approach with all steps performed via one incision.

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Bioengineering

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices
Seshasailam Venkateswaran *1, Peter J. Gwynne *2, Mei Wu 1, Ailsa Hardman 2, Annamaria Lilienkampf 1, Salvatore Pernagallo 1, Garry Blakely 2, David G. Swann 3, Mark Bradley 1, Maurice P. Gallagher 2
1School of Chemistry, EaStCHEM, University of Edinburgh, 2School of Biological Sciences, University of Edinburgh, 3Critical Care, NHS Lothian, Royal Infirmary of Edinburgh

A high-throughput microarray method for the identification of polymers which reduce bacterial surface binding on medical devices is described.

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