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Center for Research and Advanced Studies of the National Polytechnic Institute

2 ARTICLES PUBLISHED IN JoVE

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Immunology and Infection

Analysis of the Epithelial Damage Produced by Entamoeba histolytica Infection
Abigail Betanzos 1, Michael Schnoor 2, Rosario Javier-Reyna 1, Guillermina García-Rivera 1, Cecilia Bañuelos 3, Jonnatan Pais-Morales 1, Esther Orozco 1
1Department of Infectomics and Molecular Pathogenesis, Center for Research and Advanced Studies of the National Polytechnic Institute, 2Department of Molecular Biomedicine, Center for Research and Advanced Studies of the National Polytechnic Institute, 3Agency for Knowledge Commercialization, Center for Research and Advanced Studies of the National Polytechnic Institute

Human infection by Entamoeba histolytica leads to amoebiasis, a major cause of diarrhea in tropical countries. Infection is initiated by pathogen interactions with intestinal epithelial cells, provoking the opening of cell-cell contacts and consequently diarrhea, sometimes followed by liver infection. This article provides a model to assess the early host-pathogen interactions to improve our understanding of amoebiasis pathogenesis.

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Medicine

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Hilda Vargas Robles 1, Karla Fabiola Castro Ochoa 1, Porfirio Nava 2, Angélica Silva Olivares 3, Mineko Shibayama 3, Michael Schnoor 1
1Department of Molecular Biomedicine, Center for Research and Advanced Studies of the National Polytechnic Institute, 2Department of Physiology, Biophysics and Neurosciences, Center for Research and Advanced Studies of the National Polytechnic Institute, 3Department of Infectomics and Molecular Pathogenesis, Center for Research and Advanced Studies of the National Polytechnic Institute

Current treatments of inflammatory bowel diseases (IBD) aim at alleviating disease symptoms but may cause severe side effects. Thus, alternative strategies are being investigated in animal colitis models. Here, we explain how the beneficial effects of diet supplements on clinical IBD signs are analyzed in such a colitis model.

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