Institute of Oncology Ljubljana

2 ARTICLES PUBLISHED IN JoVE

Biology

¹Department of Experimental Oncology, Institute of Oncology Ljubljana, ²Faculty of Electrical Engineering, University of Ljubljana

Electrochemotherapy is a combined use of certain chemotherapeutic drugs such as cisplatin and bleomycin and electric pulses applied to the treated tumour nodule. We present the clinical protocol of electrochemotherapy for treatmen of subcutaneous and cutaneous metastases of melanoma.

Cancer Research

Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats

Natasa Tozon¹, Ursa Lampreht Tratar², Katarina Znidar³, Gregor Sersa², Justin Teissie^4,5, Maja Cemazar^2,3

¹Clinic for Surgery and Small Animals, Veterinary Faculty, University of Ljubljana, ²Department of Experimental Oncology, Institute of Oncology Ljubljana, ³Faculty of Health Sciences, University of Primorska, ⁴IPBS (Institut de Pharmacologie et de Biologie Structurale), CNRS, ⁵IPBS (Institut de Pharmacologie et de Biologie Structurale), Université de Toulouse

Electrochemotherapy is the local treatment of solid tumors. The main mechanism is electroporation-mediated permeabilization of the tumor cells' membrane which enables increased internalization of cytostatics like bleomycin and cisplatin. Thus, antitumor effectiveness is potentiated at the site of the application of electric pulses to the tumors.