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Changchun University of Chinese Medicine

4 ARTICLES PUBLISHED IN JoVE

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Biochemistry

The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension
Juanjuan Shen 1, Chunjie Hu 2, Yuan Li 1, Xiaoling Shang 1, Yue Deng 2, Jiajuan Guo 2, Lina Zhang 1, Jinfeng Wang 1, Wenfeng Zhang 1
1Changchun University of Chinese Medicine, 2First Affiliated Hospital to Changchun University of Chinese Medicine

Here, we present a protocol to induce H-type hypertension and evaluate the antihypertensive effects of Huotan Jiedu Tongluo decoction (HTJDTLD) administered intragastrically. In rats with H-type hypertension, HTJDTLD had effective antihypertensive effects, possibly associated with inhibition of endoplasmic reticulum (ER) stress-induced apoptosis pathway activation.

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Medicine

Establishment of Coloproctitis Cancer Model in Mice and Evaluation of Therapeutic Effect of Chinese Medicine
Dongxing Lyu 1, Weifang Wang 2, Hanying Xu 1, Pengfei Li 1, Wenyuan Zhang 1, Xiangyue Meng 1, Shixin Liu 3
1College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, 2School of Clinical Medicine, Changchun University of Chinese Medicine, 3Department of Radiotherapy, Jilin Provincial Cancer Hospital

This protocol provides a mouse model of ulcerative coloproctitis-associated colorectal cancer induced by azomethane combined with dextran sulfate sodium. The model was used to evaluate the efficacy of traditional Chinese medicine compounds in the prevention and treatment of colorectal cancer.

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Medicine

Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula
Miao Cui 1, Lijuan Jiang 1, Wei Yang 2, Wenfeng Zhang 1
1School of Basic Medical Science, Changchun University of Chinese Medicine, 2College of Traditional Chinese Medicine, Changchun University of Chinese Medicine

Here, we present the step-by-step protocol to investigate the therapeutic and vascular inhibitory effects of the Sanleng Jiashen formula on BALB/c-nu mice with orthotopic hepatocellular carcinoma.

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Medicine

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
Fan Li 1, Chengji Cui 2, Haiyan Yu 3, Chunguang Yi 3, Guang Ta 4, Jie Wang 1, Xu Huang 2, Yutong Liu 3, Shoulin Zhang 3
1College of Integrated Chinese and Western Medicine, Changchun University of Chinese Medicine, 2Nephropathy Department, the Affiliated Hospital to Changchun University of Chinese Medicine, 3College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, 4Internal Medicine Intensive Care Unit, the Affiliated Hospital to Changchun University of Chinese Medicine

The present protocol describes the establishment of a membranous nephropathy (MN) animal model, and how Kemeng Fang's inhibition reduces MN rat podocyte apoptosis by activating the PI3K/AKT signaling pathway.

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