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Brigham and Woman's Hospital

2 ARTICLES PUBLISHED IN JoVE

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Biology

Tracking Dynamics of Muscle Engraftment in Small Animals by In Vivo Fluorescent Imaging
Zhong Yang 1, Qing Zeng 2, Zhiyuan Ma 1, Yaming Wang 1, Xiaoyin Xu 2
1Department of Anesthesia, Brigham and Woman's Hospital, 2Department of Radiology, Brigham and Woman's Hospital

We describe an in vivo fluorescence imaging protocol to monitor muscle regeneration by GFP-labeled myoblasts after transplantation into skeletal muscles of both healthy and dystrophic mice. This protocol can be adapted to study muscle regeneration by transplantation of other types of cells and in other muscular conditions as well.

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Medicine

Hemodynamic Characterization of Rodent Models of Pulmonary Arterial Hypertension
Zhiyuan Ma 1, Lan Mao 1, Sudarshan Rajagopal 1
1Department of Medicine, Duke University Medical Center

Pulmonary arterial hypertension (PAH) is a disease of pulmonary arterioles that leads to their obliteration and the development of right ventricular failure. Rodent models of PAH are critical in understanding the pathophysiology of PAH. Here we demonstrate hemodynamic characterization, with right heart catheterization and echocardiography, in the mouse and rat.

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