Improved Visualization and Quantitative Analysis of Drug Effects Using Micropatterned CellsSébastien Degot 1, Muriel Auzan 1, Violaine Chapuis 1, Anne Béghin 2, Amélie Chadeyras 1, Constantin Nelep 1, Maria Luisa Calvo-Muñoz 1, Joanne Young 1, François Chatelain 1, Alexandra Fuchs 1
1CYTOO Cell Architects, Grenoble, France, 2Centre Commun de Quantimétrie, Faculté de Médecine Rockefeller, Lyon, France
Adhesive micropatterns that normalize cellular architecture can be used to increase sensitivity in the detection of drug effects, improve reproducibility and simplify automated image acquisition and analysis. Such technology will benefit drug/siRNA screening assays, performed on conventional cell culture supports and consequently suffering from excessive cell-to-cell variability.
