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University of Duesseldorf

2 ARTICLES PUBLISHED IN JoVE

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Immunology and Infection

Prediction of HIV-1 Coreceptor Usage (Tropism) by Sequence Analysis using a Genotypic Approach
Saleta Sierra 1, Rolf Kaiser 1, Nadine Lübke 1, Alexander Thielen 2, Eugen Schuelter 1, Eva Heger 1, Martin Däumer 3, Stefan Reuter 4, Stefan Esser 5, Gerd Fätkenheuer 6, Herbert Pfister 1, Mark Oette 7, Thomas Lengauer 2
1Institute of Virology, University of Cologne, 2Max Planck Institute for Informatics, 3Institute for Immune genetics, 4Department of Gastroenterology, Hepatology and Infectiology, University of Duesseldorf, 5Department of Dermatology, University of Essen, 6Department of Internal Medicine, University of Cologne, 7Augustinerinnen Hospital

The prediction of the coreceptor usage of HIV-1 is required for the administration of a new class of antiretroviral drugs, i.e. coreceptor antagonists. It can be performed by sequence analysis of the env gene and subsequent interpretation through an internet based interpretation system (geno2pheno[coreceptor]).

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JoVE Journal

Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using 18F-FDG PET
Alexander Grabner *1, Dominik Kentrup *1, Uta Schnöckel 2, Gert Gabriëls 1, Rita Schröter 1, Hermann Pavenstädt 1, Otmar Schober 2, Eberhard Schlatter 1, Michael Schäfers *3, Stefan Reuter *1
1Department of Internal Medicine D, Experimental Nephrology, University of Münster, 2Department of Nuclear Medicine, University of Münster, 3European Institute for Molecular Imaging, University of Münster

We herein present a rat renal transplantation model to non-invasively assess acute allograft rejection using positron emission tomography with 18F-fluorodeoxyglucose.

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