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CHU de Nantes

3 ARTICLES PUBLISHED IN JoVE

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Medicine

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice
Audrey Ayer 1, Frederic Borel 1, Francois Moreau 1, Xavier Prieur 1, Michel Neunlist 2, Bertrand Cariou 3, Claire Blanchard *1,4, Cedric Le May *1
1l'Institut du Thorax, INSERM, CNRS, UNIV Nantes, 2CHU Nantes, Institut des Maladies de l'Appareil Digestif, INSERM U913, 3l'Institut du Thorax, INSERM, CNRS, UNIV Nantes, CHU Nantes, 4Service de Clinique Chirurgicale Digestive et Endocrinienne, CHU de Nantes

Bariatric surgery is the most efficient way to reduce body weight and the deadly metabolic complications (diabetes, obesity, and dyslipidemia) frequently associated with morbid obesity. Mouse models of bariatric surgery represent a unique asset for deciphering molecular mechanisms behind the beneficial effects of these surgeries on diabetes, hypertension, and dyslipidemia.

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Medicine

Single-Anastomosis Duodeno-Ileal Bypass with Sleeve Gastrectomy Model in Mice
Samuel Frey 1,2, Audrey Ayer 1, Thibaud Sotin 1, Victoria Lorant 1, Bertrand Cariou 1, Claire Blanchard *1,2, Cédric Le May *1
1CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes Université, 2Chirurgie Cancérologique, Digestive et Endocrinienne, Institut des Maladies de l'Appareil Digestif, Hôtel Dieu, CHU Nantes

Single-anastomosis duodeno-ileal bypass (SADI-S) is an emerging bariatric procedure with important metabolic effects. In this article, we present a reliable and reproducible model of SADI-S in mice.

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Medicine

Developing a Clinically Relevant Hemorrhagic Shock Model in Rats
Thomas Dupas *1, Virginie Aillerie *1, Amandine Vergnaud 1, Thomas Pelé 1, Antoine Persello 1, Angélique Blangy-Letheule 1, Angélique Erraud 1, Mortéza Erfanian 1, Agnès Hivonnait 1, Anaïs Maillard 1, Jules Lecomte 2, Edith Bigot-Corbel 3, Aurélia A. Leroux 1,4, Manon Denis 2, Bertrand Rozec 2, Benjamin Lauzier 1
1CNRS, INSERM, l’institut du thorax, Nantes Université, 2CNRS, INSERM, l’institut du thorax, Nantes Université, CHU Nantes, 3Departement of Biochemistry, CHU de Nantes, 4Oniris

Hemorrhagic shock kills 1.9 million people worldwide every year. Small animals are frequently used as hemorrhagic shock models but are associated with issues of standardization, reproducibility, and clinical significance, thus limiting their relevance. This article describes developing a new clinically relevant hemorrhagic shock model in rats.

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