Imperial College Healthcare Trust

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Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Ryan S Thwaites¹, Hannah C Jarvis¹, Nehmat Singh¹, Akhilesh Jha¹, Andy Pritchard², Hailing Fan¹, Tanushree Tunstall¹, Joan Nanan¹, Simon Nadel², Onn Min Kon², Peter J Openshaw¹, Trevor T Hansel¹

¹National Heart and Lung Institute, Faculty of Medicine, Imperial College London, St Mary's Hospital, ²St Mary's Hospital, Imperial College Healthcare Trust

This manuscript describes the use of nasal and bronchial absorption techniques, specifically using synthetic absorptive matrices (SAM) to sample the mucosal lining fluid (MLF) of the upper and lower airway. These methods provide better standardization and tolerability than existing respiratory sampling techniques.