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United States Naval Research Laboratory

1 ARTICLES PUBLISHED IN JoVE

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Immunology and Infection

Analysis of Group IV Viral SSHHPS Using In Vitro and In Silico Methods
Xin Hu 1, Jaimee R. Compton 2, Patricia M. Legler 2
1National Center for Advancing Translational Sciences, National Institutes of Health, 2United States Naval Research Laboratory

We present a general protocol for identifying short stretches of homologous host-pathogen protein sequences (SSHHPS) embedded in the viral polyprotein. SSHHPS are recognized by viral proteases and direct the targeted destruction of specific host proteins by several Group IV viruses.

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